HLA-B alleles associated with the B15 serologically defined antigens

被引:33
作者
Steiner, N
Ng, J
Bush, J
Hartzman, RJ
Johnston-Dow, L
Hurley, CK
机构
[1] Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Sch Med, Washington, DC 20007 USA
[2] Georgetown Univ, Sch Med, Dept Pediat, Washington, DC 20007 USA
[3] USN, Med Res Inst, Bethesda, MD USA
[4] PE Appl Biosyst, Foster City, CA USA
关键词
D O I
10.1016/S0198-8859(97)00112-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cells expressing HLA molecules in the B15 family were identified by serologic typing in routine testing of volunteer donors of various ethnic backgrounds for a bone marrow registry. DNA sequencing was used to identify HLA-B15 alleles associated with each serologic type and to examine the diversity within the B15 antigen family. Alleles which appeared predominantly in each B15 serologic cluster included: B15 with no defined serologic subdivision (B*1501), B62 (B*1501), B63 (B*1516, B*1517), B75 (B*1502, B*1521), and B76/77 (B*1513). Other B*15 alleles were also found associated with the serotypes and some of these alleles (e.g., B*1501 and B*1516) were found in two or more serologic clusters illustrating the complexity of this family. The B15 unsplit and B75 groups were the most complex exhibiting 16 and 7 alleles, respectively, within each serotype. Five new B*15 alleles (B*1530, B*1531, B*1533, B*1534, B*1535) and 5 other new KLA-B alleles (B*38022, B*3910, B*4010, B*51012, and B*5108) were also identified. (C) American Society for Histocompatibility and Immunogenetics, 1997. Published by Elsevier Science Inc.
引用
收藏
页码:84 / 93
页数:10
相关论文
共 22 条
[1]   HLA CLASS-I NUCLEOTIDE-SEQUENCES, 1995 [J].
ARNETT, KL ;
PERHAM, P .
TISSUE ANTIGENS, 1995, 46 (3-2) :217-257
[2]  
BLUESTONE JA, 1993, J IMMUNOL, V151, P3943
[3]   Nomenclature for factors of the HLA system, 1996 [J].
Bodmer, JG ;
Marsh, SGE ;
Albert, ED ;
Bodmer, WF ;
Bontrop, RE ;
Charron, D ;
Dupont, B ;
Erlich, HA ;
Fauchet, R ;
Mach, B ;
Mayr, WR ;
Parham, P ;
Sasazuki, T ;
Schreuder, GMT ;
Strominger, JL ;
Svejgaard, A ;
Terasaki, PI .
TISSUE ANTIGENS, 1997, 49 (03) :297-321
[4]   MAJOR HISTOCOMPATIBILITY COMPLEX CONFORMATIONAL EPITOPES ARE PEPTIDE SPECIFIC [J].
CATIPOVIC, B ;
DALPORTO, J ;
MAGE, M ;
JOHANSEN, TE ;
SCHNECK, JP .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (06) :1611-1618
[5]   Dimorphic primers derived from intron I for use in the molecular typing of HLA-B alleles [J].
Cereb, N ;
Yang, SY .
TISSUE ANTIGENS, 1997, 50 (01) :74-76
[6]   The presence of HLA-A*2403 and HLA-B*1512 on the same haplotype in a Thai family [J].
Chandanayingyong, D ;
Adams, EJ ;
Arnett, KL ;
Hildebrand, WH ;
Parham, P ;
Lau, M .
TISSUE ANTIGENS, 1996, 47 (05) :426-427
[7]  
CHOO SY, 1993, IMMUNOGENETICS, V37, P108
[8]  
DOMENA JD, 1993, TISSUE ANTIGENS, V42, P509
[9]   A SMALL TEST OF A SEQUENCE-BASED TYPING METHOD - DEFINITION OF THE B-ASTERISK-1520 ALLELE [J].
DOMENA, JD ;
LITTLE, AM ;
ARNETT, KL ;
ADAMS, EJ ;
MARSH, SGE ;
PARHAM, P .
TISSUE ANTIGENS, 1994, 44 (04) :217-224
[10]   NUCLEOTIDE-SEQUENCE ANALYSIS OF HLA-B-ASTERISK-1523 AND B-ASTERISK-8101 - DOMINANT ALPHA-HELICAL MOTIFS PRODUCE COMPLEX SEROLOGIC RECOGNITION PATTERNS FOR THE HLA-B''DT'' AND HLA-B''NM5'' ANTIGENS [J].
ELLEXSON, ME ;
ZHANG, GZ ;
STEWART, D ;
LAU, M ;
TERESI, G ;
TERASAKI, P ;
ROE, B ;
HILDEBRAND, W .
HUMAN IMMUNOLOGY, 1995, 44 (02) :103-110