PIN1, the cell cycle and cancer

被引：223

作者：

Yeh, Elizabeth S.

Means, Anthony R.

机构：

[1] Duke Univ, Med Ctr, Levine Sci Res Ctr C238, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[2] Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc2107

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and so affect protein function and/ or stability. PIN1 regulates a number of proteins important for cell-cycle progression and, based on gain- and loss-of-function studies, is presumed to operate as a molecular timer of this important process. Therefore, it seems logical that alterations in the level of PIN1 can influence hyperproliferative diseases such as cancer. However, the precise role of PIN1 in cancer remains controversial.

引用

收藏

页码：381 / 388

页数：8

相关论文

共 93 条

[1] Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p2l, p27, and antiestrogens in breast cancer [J].

Akli, S ;

Zheng, PJ ;

Multani, AS ;

Wingate, HF ;

Pathak, S ;

Zhang, N ;

Tucker, SL ;

Chang, S ;

Keyomarsi, K .

CANCER RESEARCH, 2004, 64 (09) :3198-3208

[2] Spermatogonial depletion in adult Pin1-deficient mice [J].

Atchison, FW ;

Means, AR .

BIOLOGY OF REPRODUCTION, 2003, 69 (06) :1989-1997

[3] Pin1 regulates the timing of mammalian primordial germ cell proliferation [J].

Atchison, FW ;

Capel, B ;

Means, AR .

DEVELOPMENT, 2003, 130 (15) :3579-3586

[4]

Ayala G, 2003, CANCER RES, V63, P6244

[5] Prevalent overexpression of prolyl isomerase Pin1 in human cancers [J].

Bao, L ;

Kimzey, A ;

Sauter, G ;

Sowadski, JM ;

Lu, KP ;

Wang, DG .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (05) :1727-1737

[6]

Basu A, 2002, INT J ONCOL, V21, P597

[7] Proteasomal degradation of human peptidyl prolyl isomerase Pin1-pointing phospho Bcl2 toward dephosphorylation [J].

Basu, A ;

Das, M ;

Qanungo, S ;

Fan, CJ ;

DuBois, G ;

Haldar, S .

NEOPLASIA, 2002, 4 (03) :218-227

[8] Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery [J].

Becker, EBE ;

Bonni, A .

NEURON, 2006, 49 (05) :655-662

[9] Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage [J].

Berger, M ;

Stahl, N ;

Del Sal, G ;

Haupt, Y .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (13) :5380-5388

[10] The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77 retinoic acid receptor α stability [J].

Brondani, V ;

Schefer, Q ;

Hamy, F ;

Klimkait, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 328 (01) :6-13

← 1 2 3 4 5 6 7 8 9 10 →