Synthesis and reactivity of α-halogenated, C-protected β-enamino acids

被引：3

作者：

Fustero, S ^{[1
]}

Salavert, E ^{[1
]}

Sanz-Cervera, JF ^{[1
]}

Román, R ^{[1
]}

Fernández-Gutiérrez, BF ^{[1
]}

Asensio, A ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain

来源：

LETTERS IN ORGANIC CHEMISTRY | 2004年 / 1卷 / 02期

关键词：

halogenation; beta-enamino acid; uracil; oxazoline;

D O I：

10.2174/1570178043488545

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-Protected beta-enamino acids (I) reacted with one equivalent of N-halosuccinimides (NXS) to furnish their alpha-halogenated derivatives (II). These compounds were then successfully transformed into halogenated Uracil derivatives (III) through reaction with triphosgene. followed by 5-membered ring-opening under acidic conditions.

引用

页码：163 / 167

页数：5

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[1] CYANOGEN-BROMIDE AS A USEFUL BROMINATING AGENT - SYNTHESIS OF ALPHA-BROMO-BETA-AMINOENONES [J].