Separation anxiety at the centromere

被引：33

作者：

Dej, KJ ^{[1
]}

Orr-Weaver, TL ^{[1
]}

机构：

[1] Nine Cambridge Ctr, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(00)01821-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During mitosis, replicated sister chromatids must maintain cohesion as they attach to the mitotic spindle. At anaphase, cohesion is lost simultaneously along the entire chromosome, releasing sisters from one another and allowing them to segregate to opposite poles. During meiosis, sisters separate in a two-step process. At anaphase of meiosis I, cohesion is lost along the chromosome arms but is maintained at centromeric regions. Not until meiosis II are sister chromatic-is able to break the connection at the centromere and separate away from one another. Recent studies suggest that the centromere exhibits dynamics that are very different compared with those of the chromatid arms during both mitosis and meiosis. This review discusses the nature of the specialized chromatid cohesion seen at the centromere.

引用

页码：392 / 399

页数：8

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