Electrospun nanofibrous materials for tissue engineering and drug delivery

被引：384

作者：

Cui, Wenguo ^{[1
]}

Zhou, Yue ^{[1
]}

Chang, Jiang ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Med Res Inst 10, Shanghai 200030, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China

来源：

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS | 2010年 / 11卷 / 01期

关键词：

electrospinning; nanofiber; tissue engineering; drug delivery; LABILE BIODEGRADABLE POLYMERS; UNIAXIALLY ALIGNED ARRAYS; IN-SITU GROWTH; POLY(DL-LACTIDE) FIBERS; ULTRAFINE FIBERS; POTENTIAL SCAFFOLDS; ABDOMINAL ADHESIONS; CONTROLLED-RELEASE; SUSTAINED-RELEASE; HIGH-POROSITY;

D O I：

10.1088/1468-6996/11/1/014108

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

The electrospinning technique, which was invented about 100 years ago, has attracted more attention in recent years due to its possible biomedical applications. Electrospun fibers with high surface area to volume ratio and structures mimicking extracellular matrix (ECM) have shown great potential in tissue engineering and drug delivery. In order to develop electrospun fibers for these applications, different biocompatible materials have been used to fabricate fibers with different structures and morphologies, such as single fibers with different composition and structures (blending and core-shell composite fibers) and fiber assemblies (fiber bundles, membranes and scaffolds). This review summarizes the electrospinning techniques which control the composition and structures of the nanofibrous materials. It also outlines possible applications of these fibrous materials in skin, blood vessels, nervous system and bone tissue engineering, as well as in drug delivery.

引用

页数：11

共 89 条

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[3]

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