Molybdenum-containing hydroxylases

被引：242

作者：

Hille, R ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2005年 / 433卷 / 01期

关键词：

molybdenum; xanthine oxidoreductase; xanthine dehydrogenase; aldehyde oxidoreductase; catalytic mechanism;

D O I：

10.1016/j.abb.2004.08.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Unlike monooxygenases, molybdenum-containing hydroxylases catalyze the hydroxylation of carbon centers using oxygen derived ultimately from water, rather than O-2, as the source of the oxygen atom incorporated into the product, and do not require an external source of reducing equivalents. The mechanism by which this interesting chemistry takes place has been the subject of investigation for some time, and in the last several years the chemical Course of the reaction has become increasingly well understood. The present minireview summarizes recent mechanistic and structure/function studies of members of this large and growing family of enzymes. (C) 2004 Elsevier Inc. All rights reserved.

引用

收藏

页码：107 / 116

页数：10

相关论文

共 58 条

[1]

LASER FLASH-PHOTOLYSIS STUDIES OF INTRAMOLECULAR ELECTRON-TRANSFER IN MILK XANTHINE-OXIDASE [J].

BHATTACHARYYA, A ;

TOLLIN, G ;

DAVIS, M ;

EDMONDSON, DE .

BIOCHEMISTRY, 1983, 22 (23) :5270-5279

[2]

ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana [J].

Bittner, F ;

Oreb, M ;

Mendel, RR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (44) :40381-40384

[3]

X-RAY ABSORPTION-SPECTROSCOPY OF XANTHINE-OXIDASE - THE MOLYBDENUM CENTERS OF THE FUNCTIONAL AND THE DESULFO FORMS [J].

BORDAS, J ;

BRAY, RC ;

GARNER, CD ;

GUTTERIDGE, S ;

HASNAIN, SS .

BIOCHEMICAL JOURNAL, 1980, 191 (02) :499-508

[4]

BRAY RC, 1964, J BIOL CHEM, V239, P2667

[5]

RAPIDLY APPEARING MOLYBDENUM ELECTRON-PARAMAGNETIC-RESONANCE SIGNALS FROM REDUCED XANTHINE OXIDASE [J].

BRAY, RC ;

VANNGARD, T .

BIOCHEMICAL JOURNAL, 1969, 114 (04) :725-&

[6]

ELECTRON-PARAMAGNETIC-RESONANCE STUDIES USING PRE-STEADY-STATE KINETICS AND SUBSTITUTION WITH STABLE ISOTOPES ON THE MECHANISM OF ACTION OF MOLYBDOENZYMES [J].

BRAY, RC ;

GEORGE, GN .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1985, 13 (03) :560-567

[7]

STRUCTURE OF A HYPERTHERMOPHILIC TUNGSTOPTERIN ENZYME, ALDEHYDE FERREDOXIN OXIDOREDUCTASE [J].

CHAN, MK ;

MUKUND, S ;

KLETZIN, A ;

ADAMS, MWW ;

REES, DC .

SCIENCE, 1995, 267 (5203) :1463-1469

[8]

REACTIVITY OF THE MO(O)(S) FUNCTIONAL-GROUP IN THE [(L)MO(O)(MU-S)2MO(O)(S)]N- DIMERIC THIOMOLYBDATE COMPLEXES (L=C5H5-, N=1-,S4(2-), N=2) AND IMPLICATIONS REGARDING THE FUNCTION OF XANTHINE-OXIDASE - SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF [(DMF)3MO(O)(MU-S)2MO(O)(S2)], [PH4P][(C5H5)MO(O)(MU-S)2MO(O)(S2)], [PH4P]2[(S4)MO(O)(MU-S)2MO(O)(S)], AND (ET4N)4([(S4)MO(O)(MU-S)2MO(O)(S)]2) [J].

COUCOUVANIS, D ;

TOUPADAKIS, A ;

LANE, JD ;

KOO, SM ;

KIM, CG ;

HADJIKYRIACOU, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (14) :5271-5282

[9]

MOLYBDENUM SITES OF SULFITE OXIDASE AND XANTHINE DEHYDROGENASE - A COMPARISON BY EXAFS [J].

CRAMER, SP ;

WAHL, R ;

RAJAGOPALAN, KV .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (26) :7721-7727

[10]

DAVIS MD, 1982, J BIOL CHEM, V257, P4730

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