Isolation and characterization of tetracycline-resistant clinical isolates of Helicobacter pylori

被引：38

作者：

Kwon, DH

Kim, JJ

Lee, M

Yamaoka, Y

Kato, M

Osato, MS

El-Zaatari, FAK

Graham, DY

机构：

[1] Vet Affairs Med Ctr, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea

[4] Hokkaido Univ, Sch Med, Dept Endoscopy, Sapporo, Hokkaido 060, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 11期

关键词：

D O I：

10.1128/AAC.44.11.3203-3205.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 mug/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracycline-resistant isolates exhibited cross-resistance to metronidazole, and the cross-resistance was transferred to tetracycline-sensitive H. pylori strains.

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页码：3203 / 3205

页数：3

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