Cytotoxicity of extractives from Taiwania cryptomerioides heart-wood

被引：98

作者：

Chang, ST ^{[1
]}

Wang, DSY

Wu, CL

Shiah, SG

Kuo, YH

Chang, CJ

机构：

[1] Natl Taiwan Univ, Dept Forestry, Taipei 106, Taiwan

[2] Acad Sinica, Inst Bioagr Sci, Taipei 115, Taiwan

[3] Natl Hlth Res Inst, Taipei 115, Taiwan

[4] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[5] Purdue Univ, Sch Pharm & Pharmacal Sci, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

PHYTOCHEMISTRY | 2000年 / 55卷 / 03期

关键词：

Taiwania cryptomerioides; lignan; sesquiterpenoid; taiwanin A; taiwanin E; dimethylmatairesinol; cytotoxicity; apoptosis;

D O I：

10.1016/S0031-9422(00)00275-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated. Three human tumor cells including A-549 lung carcinoma, MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells. Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the turner cell death induced by taiwanin A was due to apoptosis. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：227 / 232

页数：6

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