Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung

被引:63
作者
Hashimoto, M
Wang, DY
Kamo, T
Zhu, Y
Tsujiuchi, T
Konishi, Y
Tanaka, M
Sugimura, H
机构
[1] Hamamatsu Univ Sch Med, Dept Pathol 1, Hamamatsu, Shizuoka 4313192, Japan
[2] China Med Univ, Canc Res Inst, Shenyang, Peoples R China
[3] Nara Med Univ, Ctr Canc, Dept Oncol Pathol, Nara, Japan
关键词
D O I
10.1016/S0002-9440(10)64512-9
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Differential display analysis of rat lung at different developmental stages identified a fragment, HG80, which appeared on embryonic day 16.5 and thereafter. A full-length cDNA derived from a cDNA library of newborn rat lung probed with HG80 was the rat counterpart of sodium-dependent phosphate transporter type IIb, and was designated rNaPi IIb, In situ hybridization showed that rNaPi IIb was expressed in type II alveolar cells, suggesting a role in the synthesis of surfactant in the alveoli. The time-dependent changes in localization of this gene in the developing lung and its possible use as a type II pneumocyte marker are discussed.
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页码:21 / 27
页数:7
相关论文
共 24 条
[1]   ROLE OF HEPATOCYTE NUCLEAR FACTOR-3-ALPHA AND HEPATOCYTE NUCLEAR FACTOR-3-BETA IN CLARA CELL SECRETORY PROTEIN GENE-EXPRESSION IN THE BRONCHIOLAR EPITHELIUM [J].
BINGLE, CD ;
HACKETT, BP ;
MOXLEY, M ;
LONGMORE, W ;
GITLIN, JD .
BIOCHEMICAL JOURNAL, 1995, 308 :197-202
[2]  
BOGUE CW, 1994, AM J PHYSIOL, V266, P448
[3]   STRUCTURAL-ANALYSIS OF FETAL-RAT LUNG DEVELOPMENT [J].
BURRI, PH ;
MOSCHOPULOS, M .
ANATOMICAL RECORD, 1992, 234 (03) :399-418
[4]  
Cardoso WV, 1996, DEV DYNAM, V207, P47, DOI 10.1002/(SICI)1097-0177(199609)207:1<47::AID-AJA6>3.0.CO
[5]  
2-W
[6]   SODIUM-DEPENDENT PHOSPHATE AND ALANINE TRANSPORTS BUT SODIUM-INDEPENDENT HEXOSE-TRANSPORT IN TYPE-II ALVEOLAR EPITHELIAL-CELLS IN PRIMARY CULTURE [J].
CLERICI, C ;
SOLER, P ;
SAUMON, G .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1063 (01) :27-35
[7]   MEMBERS OF THE HNF-3 FORKHEAD FAMILY OF TRANSCRIPTION FACTORS EXHIBIT DISTINCT CELLULAR EXPRESSION PATTERNS IN LUNG AND REGULATE THE SURFACTANT PROTEIN-B PROMOTER [J].
CLEVIDENCE, DE ;
OVERDIER, DG ;
PETERSON, RS ;
PORCELLA, A ;
YE, HG ;
PAULSON, KE ;
COSTA, RH .
DEVELOPMENTAL BIOLOGY, 1994, 166 (01) :195-209
[8]  
DOLLE P, 1990, DEVELOPMENT, V110, P1133
[9]   Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine [J].
Feild, JA ;
Zhang, L ;
Brun, KA ;
Brooks, DP ;
Edwards, RM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (03) :578-582
[10]   NUCLEOTIDE AND DEDUCED AMINO-ACID SEQUENCE OF THE HYDROPHOBIC SURFACTANT PROTEIN SP-C FROM RAT - EXPRESSION IN ALVEOLAR TYPE-II CELLS AND HOMOLOGY WITH SP-C FROM OTHER SPECIES [J].
FISHER, JH ;
SHANNON, JM ;
HOFMANN, T ;
MASON, RJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 995 (03) :225-230