The putative glycosyltransferase-encoding gene cylJ and the group B streptococcus (GBS)-specific gene cylK modulate hemolysin production and virulence of GBS

被引：37

作者：

Forquin, Marie-Pierre

Tazi, Asmae

Rosa-Fraile, Manuel

Poyart, Claire

Trieu-Cuot, Patrick

Dramsi, Shaynoor

机构：

[1] Inst Pasteur, Unite Biol Bacteries Pathogenes Gram Positif, URA CNRS 2172, F-75724 Paris 15, France

[2] Univ Paris 05, Inst Cochin, INSERM 4567, UMR 810,CNRS, Paris, France

[3] Virgen Nieves Univ Hosp, Microbiol Serv, Granada, Spain

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 04期

关键词：

D O I：

10.1128/IAI.01565-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Group B streptococcus (GBS) expresses a hemolysin/cytolysin that plays an important role in pathogenesis. Using the Himar1 transposon mutagenesis system, a hypohemolytic mutant carrying an interrupted cylJ gene was characterized. cylJ, encoding a putative glycosyltransferase, and cylK, whose product is unknown, are both required for the full hemolytic/cytolytic activity, pigment formation, and virulence of GBS.

引用

页码：2063 / 2066

页数：4

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