Genetic control of sodium channel function

被引：126

作者：

Tan, HL

Bezzina, CR

Smits, JPP

Verkerk, AO

Wilde, AAM

机构：

[1] Acad Med Ctr, Dept Cardiol, Expt & Mol Cardiol Grp, NL-1100 DE Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1012 WX Amsterdam, Netherlands

来源：

CARDIOVASCULAR RESEARCH | 2003年 / 57卷 / 04期

关键词：

arrhythmia mechanisms; long QT syndrome; Na-channel; sudden death; ventricular arrhythmias;

D O I：

10.1016/S0008-6363(02)00714-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sodium ion (Na) influx through cardiac Na channels triggers the action potential in cells of the working myocardium and the specialized conduction system. Na channels thus act as key molecular determinants of cardiac excitability and impulse propagation. Na channel dysfunction may cause life-threatening arrhythmias. Here, we review the ways in which Na channel function can be aberrant due to genetic changes. We discuss how biophysical studies of mutant Na channels combined with precise clinical phenotyping may improve our understanding of Na channel function in health and disease and may be useful as a model from which to derive improved treatment strategies for common disease. (C) 2003 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.

引用

收藏

页码：961 / 973

页数：13

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