Systems biology and heart failure: concepts, methods, and potential research applications

被引：15

作者：

Adams, Kirkwood F. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Sch Med, UNC Heart Failure Program, Dept Med, Chapel Hill, NC 27514 USA

[2] Univ N Carolina, Sch Med, UNC Heart Failure Program, Dept Radiol, Chapel Hill, NC 27514 USA

来源：

HEART FAILURE REVIEWS | 2010年 / 15卷 / 04期

关键词：

Systems biology; Modular biology; Genomics; Genome-wide scanning; GENOME-WIDE ASSOCIATION; ANGIOTENSIN-CONVERTING ENZYME; COPY-NUMBER VARIATION; NATRIURETIC-PEPTIDE; GENE-EXPRESSION; LINKAGE DISEQUILIBRIUM; CENTRAL DOGMA; POSTTRANSLATIONAL MODIFICATIONS; TRANSCRIPTOMIC BIOMARKERS; ESSENTIAL-HYPERTENSION;

D O I：

10.1007/s10741-009-9138-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dramatic advances in molecular biology dominated twentieth century biomedical science and delineated the function of individual genes and molecules in exquisite detail. However, biological processes cannot be fully understood based on the properties of individual genes and molecules alone, since these elements act in concert to enable the specific functions that make for living cells and organisms. The discipline of systems biology provides a novel conceptual framework for understanding biological phenomenon. Systems biology synthesizes information concerning the interactions of genes and molecules and allows characterization of the supramolecular networks and functional modules that represent the most essential aspects of cell organization and physiology.

引用

页码：371 / 398

页数：28

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