Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease

被引:49
作者
Dal Pra, C
Chen, S
Furmaniak, J
Smith, BR
Pedini, B
Moscon, A
Zanchetta, R
Betterle, C
机构
[1] Univ Padua, Dept Med & Surg Sci, Div Endocrinol, Padua, Italy
[2] Univ Padua, Chair Clin Immunol & Allergy, Padua, Italy
[3] Univ Wales Coll Cardiff, Coll Med, Dept Med, Cardiff CF1 3NS, S Glam, Wales
[4] RSR Ltd, FIRS Labs, Cardiff, S Glam, Wales
关键词
D O I
10.1530/eje.0.1480565
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Design: Adrenal cortex autoantibodies (ACA), steroid-producing cell autoantibodies (StCA) and autoantibodies (Abs) to steroidogenic enzymes in three groups of patients with premature ovarian failure (POF), 15 with autoimmune Addison's disease (AD), 2 6 with non-adrenal autoimmune diseases and 31 with isolated POF, have been assessed. Methods: ACA and StCA were measured using an immunofluorescence technique. Abs to 21-hydroxylase (21-OH), to 17alpha-hydroxylase (17alpha-OH) and to cytochrome P450 side-chain cleavage (P450scc) were measured using an immunoprecipitation assay. Results: Seventy-three percent of patients with POF and AD were positive for StCA, 93% for 17alpha-OH and/or P450scc Abs, 93% for ACA and 100% for 21-OH Abs. Among patients with POF and non-adrenal autoimmune diseases, 8% were positive for StCA, 12% for 17alpha-OH and/or P450scc Abs, and 8% and 12% for ACA and 21-OH Abs respectively. StCA, 17alpha-OH and/or P450scc Abs were all found in 10% of patients with isolated POF, and 13% had ACA and 21-OH Abs. All StCA-,17alpha-OH- and/or P450scc Abs-positive patients were also positive for ACA and 21-OH Abs. Two patients with isolated POF who were ACA and 21-OH Ab positive developed AD 3 and 5 years after the onset of POF. Conclusion: This study has shown that, when POF is associated with AD, StCA, 17alpha-OH and/or P450scc Abs are present in the majority of patients, while in the other two groups these Abs are detectable in a much lower proportion of patients. Measurement of ACA/21-OH Abs in some patients with POF may be important in identifying patients at risk of developing overt AD.
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页码:565 / 570
页数:6
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