Coasting may reduce the severity of the ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome

被引：12

作者：

Ohata, Y ^{[1
]}

Harada, T ^{[1
]}

Ito, M ^{[1
]}

Yoshida, S ^{[1
]}

Iwabe, T ^{[1
]}

Terakawa, N ^{[1
]}

机构：

[1] Tottori Univ, Sch Med, Dept Obstet & Gynecol, Yonago, Tottori 6838504, Japan

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2000年 / 50卷 / 03期

关键词：

coasting; polycystic ovary; ovarian hyperstimulation syndrome; in vitro fertilization and embryo transfer; chorionic gonadotropin; human;

D O I：

10.1159/000010307

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of our study was to determine the efficacy of postponing administration of human chorionic gonadotropin while continuing daily gonadotropin-releasing hormone agonist therapy ('coasting') to prevent the occurrence of severe ovarian hyperstimulation syndrome (OHSS) for patients with polycystic ovary (PCO) syndrome. Five patients with PCO who had been hospitalized due to severe OHSS in previous in vitro fertilization and embryo transfer or intrauterine insemination cycles at the Tottori University Hospital were included in the study. The rates of mature oocytes and fertilization were comparable between the cycles, A singleton pregnancy was achieved in a patient during the coasting cycle, and none of the women developed severe OHSS in coasting cycles. The results suggest that coasting may be an alternative method for reducing the severity of OHSS in patients with PCO. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：186 / 188

页数：3

共 12 条

[1] Withholding gonadotropin administration is an effective alternative for the prevention of ovarian hyperstimulation syndrome [J].

Benadiva, CA ;

Davis, O ;

Kligman, I ;

Moomjy, M ;

Liu, HC ;

Rosenwaks, Z .

FERTILITY AND STERILITY, 1997, 67 (04) :724-727

[2] Intravenous albumin does not prevent the development of severe ovarian hyperstimulation syndrome [J].

Chen, CD ;

Wu, MY ;

Yang, JH ;

Chen, SU ;

Ho, HN ;

Yang, YS .

FERTILITY AND STERILITY, 1997, 68 (02) :287-291

[3]

DEMETRIOS M, 1995, AM J OBSTET GYNECOL, V172, P1518

[4] Prevention of severe ovarian hyperstimulation by coasting [J].

Dhont, M ;

Van der Straeten, F ;

De Sutter, P .

FERTILITY AND STERILITY, 1998, 70 (05) :847-850

[5]

Elchalal U, 1997, HUM REPROD, V12, P1129

[6] Altering the timing of human chorionic gonadotropin injection according to serum progesterone (P) concentrations improves embryo quality in cycles with subtle P rise [J].

Harada, T ;

Katagiri, C ;

Takao, N ;

Toda, T ;

Mio, Y ;

Terakawa, N .

FERTILITY AND STERILITY, 1996, 65 (03) :594-597

[7] Vascular endothelial growth factor levels in serum and follicular fluid of patients undergoing in vitro fertilization [J].

Lee, A ;

Christenson, LK ;

Stouffer, RL ;

Burry, KA ;

Patton, PE .

FERTILITY AND STERILITY, 1997, 68 (02) :305-311

[8]

NAVOT D, 1992, FERTIL STERIL, V58, P249

[9] HUMAN CHORIONIC GONADOTROPIN-DEPENDENT EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR VASCULAR-PERMEABILITY FACTOR IN HUMAN GRANULOSA-CELLS - IMPORTANCE IN OVARIAN HYPERSTIMULATION SYNDROME [J].

NEULEN, J ;

YAN, ZP ;

RACZEK, S ;

WEINDEL, K ;

KECK, C ;

WEICH, HA ;

MARME, D ;

BRECKWOLDT, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (06) :1967-1971

[10] 'Prolonged coasting': An effective method for preventing severe ovarian hyperstimulation syndrome in patients undergoing in-vitro fertilization [J].

Sher, G ;

Zouves, C ;

Feinman, M ;

Maassarani, G .

HUMAN REPRODUCTION, 1995, 10 (12) :3107-3109

← 1 2 →