β-homolysine oligomers:: A new class of Trojan carriers

被引：18

作者：

Garcia-Echeverría, C ^{[1
]}

Ruetz, S ^{[1
]}

机构：

[1] Novartis Pharma Inc, Oncol Res, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(02)00885-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe the design, synthesis and cell-membrane translocation properties of a series of beta-peptides with the general sequence fluorescein-Adoa-(beta-homolysine)(n)-NH2, n = 5-8 and Adoa = 8-amino-3,6-dioxaoctanoic acid. These beta-peptides are able to cross the cytoplasmic membrane and accumulate in the nucleus of mammalian cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：247 / 251

页数：5

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