Call of the wild: antibiotic resistance genes in natural environments

被引：1602

作者：

Allen, Heather K. ^{[1
,2
,3
]}

Donato, Justin ^{[1
,2
]}

Wang, Helena Huimi ^{[4
]}

Cloud-Hansen, Karen A. ^{[1
,2
]}

Davies, Julian ^{[4
]}

Handelsman, Jo ^{[5
]}

机构：

[1] Univ Wisconsin Madison, Dept Bacteriol, Madison, WI 53706 USA

[2] Univ Wisconsin Madison, Dept Plant Pathol, Madison, WI 53706 USA

[3] Univ Wisconsin Madison, Microbiol Doctoral Training Program, Madison, WI 53706 USA

[4] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada

[5] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HEAVY-METAL RESISTANCE; FUNGUS-GROWING ANTS; ESCHERICHIA-COLI; ANTIMICROBIAL RESISTANCE; STAPHYLOCOCCUS-AUREUS; BETA-LACTAMASES; HIGH PREVALENCE; SOIL BACTERIA; CHLORAMPHENICOL; INTEGRONS;

D O I：

10.1038/nrmicro2312

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibiotic-resistant pathogens are profoundly important to human health, but the environmental reservoirs of resistance determinants are poorly understood. The origins of antibiotic resistance in the environment is relevant to human health because of the increasing importance of zoonotic diseases as well as the need for predicting emerging resistant pathogens. This Review explores the presence and spread of antibiotic resistance in non-agricultural, non-clinical environments and demonstrates the need for more intensive investigation on this subject.

引用

页码：251 / 259

页数：9