Synthesis of granulatimide analogues bearing a maleimide instead of an imidazole heterocycle

被引：27

作者：

Hugon, B

Pfeiffer, B

Renard, P

Prudhomme, M ^{[1
]}

机构：

[1] Univ Clermont Ferrand, UMR 6504, CNRS, F-63177 Aubiere, France

[2] Labs SERVIER, F-92415 Courbevoie, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 20期

关键词：

G2 checkpoint inhibitors; granulatimide; dipyrrolocarbazole tetraone;

D O I：

10.1016/S0040-4039(03)00823-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis in a few steps of a new family of granulatimide analogues was performed. In the new compounds, the aromatic framework of granulatimide is modified by replacement of the imidazole unit by a maleimide moiety. The synthesis of a water-soluble analogue is also presented. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：3935 / 3937

页数：3

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