Elevated clotting factor levels and venous thrombosis

被引:45
作者
Bertina, RM [1 ]
机构
[1] Leiden Univ, Med Ctr, Dept Hematol, Hemostasis & Thrombosis Res Ctr, Leiden, Netherlands
关键词
elevated clotting factor levels; venous thrombosis; factor VIII; factor IX; factor XI; prothrombin; fibrinogen;
D O I
10.1159/000083835
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Increased plasma levels of fibrinogen, factor VIII (FVIII), factor IX (FIX), factor XI (FXI) and prothrombin all were reported to be independent risk factors of venous thromboembolism (VTE). However there is only limited information on the molecular basis of these plasma phenotypes. In addition some of these plasma phenotypes may form clusters, which may point to defects in common pathways affecting biosynthesis or clearance. Uncertainties as to what should be considered the cut-off for an elevated plasma level and in some cases (FIX, FXI) the lack of published confirmatory and/or prospective studies, have delayed the incorporation of these parameters in thrombophilia screening procedures. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:395 / 400
页数:6
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