Gene vaccination: plasmid DNA is more than just a blueprint

被引:292
作者
Tighe, H
Corr, M
Roman, M
Raz, E
机构
[1] Univ Calif San Diego, Dept Med, San Diego, CA 92093 USA
[2] Univ Calif San Diego, Sam & Rose Stein Inst Res Aging, San Diego, CA 92093 USA
[3] Dynavax Technol Corp, San Diego, CA 92121 USA
来源
IMMUNOLOGY TODAY | 1998年 / 19卷 / 02期
关键词
D O I
10.1016/S0167-5699(97)01201-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Despite the popularity of using plasmid DNA for vaccination, it is only recently that the basic mechanisms that drive the immune response to the encoded antigen have begun to unfold. Here, Helen Tighe and colleagues outline the characteristics of the immune response induced by gene vaccination and describe the multifaceted properties of DNA in initiating and determining the process.
引用
收藏
页码:89 / 97
页数:9
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