Defining the role of mTOR in cancer

被引：3053

作者：

Guertin, David A.

Sabatini, David M.

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02141 USA

[2] MIT, Dept Biol, Cambridge, MA 02141 USA

[3] Broad Inst, Cambridge Ctr 7, Cambridge, MA 02141 USA

[4] MIT, Cambridge, MA 02139 USA

[5] Canc Res Ctr, Cambridge, MA 02139 USA

来源：

CANCER CELL | 2007年 / 12卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2007.05.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-signaling pathways commonly deregulated in human cancers. This has led to the prediction that mTOR inhibitors may be useful in oncology, and derivatives of one such molecule, rapamycin (from which mTOR derives its name), are currently in clinical development. In this review, we discuss recent progress in understanding mTOR signaling, paying particular attention to its relevance in cancer. We further discuss the use of rapamycin in oncology and conclude with a discussion on the future of mTOR-targeted therapy.

引用

收藏

页码：9 / 22

页数：14

相关论文

共 138 条

[1]

Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis [J].

Ackah, E ;

Yu, J ;

Zoellner, S ;

Iwakiri, Y ;

Skurk, C ;

Shibata, R ;

Ouchi, N ;

Easton, RM ;

Galasso, G ;

Birnbaum, MJ ;

Walsh, K ;

Sessa, WC .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (08) :2119-2127

[2]

Mechanism of activation of protein kinase B by insulin and IGF-1 [J].

Alessi, DR ;

Andjelkovic, M ;

Caudwell, B ;

Cron, P ;

Morrice, N ;

Cohen, P ;

Hemmings, BA .

EMBO JOURNAL, 1996, 15 (23) :6541-6551

[3]

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site [J].

Ali, SM ;

Sabatini, DM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (20) :19445-19448

[4]

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling [J].

Baba, Masaya ;

Hong, Seung-Beom ;

Sharma, Nirmala ;

Warren, Michelle B. ;

Nickerson, Michael L. ;

Iwamatsu, Akihiro ;

Esposito, Dominic ;

Gillette, William K. ;

Hopkins, Ralph F., III ;

Hartley, James L. ;

Furihata, Mutsuo ;

Oishi, Shinya ;

Zhen, Wei ;

Burke, Terrence R., Jr. ;

Linehan, W. Marston ;

Schmidt, Laura S. ;

Zbar, Berton .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (42) :15552-15557

[5]

A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1 [J].

Bachmann, RA ;

Kim, JH ;

Wu, AL ;

Park, IH ;

Chen, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (11) :7357-7363

[6]

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors [J].

Ballif, BA ;

Roux, PP ;

Gerber, SA ;

MacKeigan, JP ;

Blenis, J ;

Gygi, SP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (03) :667-672

[7]

PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR [J].

Bernardi, Rosa ;

Guernah, Ilhem ;

Jin, David ;

Grisendi, Silvia ;

Alimonti, Andrea ;

Teruya-Feldstein, Julie ;

Cordon-Cardo, Carlos ;

Simon, M. Celeste ;

Rafii, Shahin ;

Pandolfi, Pier Paolo .

NATURE, 2006, 442 (7104) :779-785

[8]

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB [J].

Biondi, RM ;

Kieloch, A ;

Currie, RA ;

Deak, M ;

Alessi, DR .

EMBO JOURNAL, 2001, 20 (16) :4380-4390

[9]

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms [J].

Brognard, John ;

Sierecki, Emma ;

Gao, Tianyan ;

Newton, Alexandra C. .

MOLECULAR CELL, 2007, 25 (06) :917-931

[10]

Localization of Rheb to the endomembrane is critical for its signaling function [J].

Buerger, Claudia ;

DeVries, Ben ;

Stambolic, Vuk .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 344 (03) :869-880

← 1 2 3 4 5 6 7 8 9 10 →