Cellular signaling and factors involved in Muller cell gliosis: Neuroprotective and detrimental effects

被引:627
作者
Bringmann, Andreas [1 ,3 ]
Iandiev, Ianors [1 ,3 ]
Pannicke, Thomas [2 ]
Wurm, Antje [2 ]
Hollborn, Margrit [1 ,3 ]
Wiedemann, Peter [1 ,3 ]
Osborne, Neville N. [4 ]
Reichenbach, Andreas [2 ]
机构
[1] Univ Leipzig, Dept Ophthalmol, D-04103 Leipzig, Germany
[2] Univ Leipzig, Paul Flechsig Inst Brain Res, D-04109 Leipzig, Germany
[3] Univ Leipzig, Hosp Eye, D-04103 Leipzig, Germany
[4] Univ Oxford, Nuffield Lab Ophthalmol, Oxford OX3 9DU, England
关键词
Muller cell; Gliosis; Neuroprotection; Immunomodulation; Proliferation; Neural progenitor; FIBROBLAST-GROWTH-FACTOR; RETINAL GLIAL-CELLS; FIBRILLARY ACIDIC PROTEIN; TUMOR-NECROSIS-FACTOR; CILIARY NEUROTROPHIC FACTOR; ISCHEMIA-REPERFUSION INJURY; PRESSURE-INDUCED ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE SYNTHASE; ADULT HUMAN RETINA;
D O I
10.1016/j.preteyeres.2009.07.001
中图分类号
R77 [眼科学];
学科分类号
100212 [眼科学];
摘要
Muller cells are active players in normal retinal function and in virtually all forms of retinal injury and disease. Reactive Willer cells protect the tissue from further damage and preserve tissue function by the release of antioxidants and neurotrophic factors, and may contribute to retinal regeneration by the generation of neural progenitor/stem cells. However, Muller cell gliosis can also contribute to neurodegeneration and impedes regenerative processes in the retinal tissue by the formation of glial scars. This article provides an overview of the neuroprotective and detrimental effects of Muller cell gliosis, with accounts on the cellular signal transduction mechanisms and factors which are implicated in Muller cell-mediated neuroprotection, immunomodulation, regulation of Muller cell proliferation, upregulation of intermediate filaments,glial scar formation, and the generation of neural progenitor/stem cells. A proper understanding of the signaling mechanisms implicated in gliotic alterations of Muller cells is essential for the development of efficient therapeutic strategies that increase the supportive/protective and decrease the destructive roles of gliosis. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:423 / 451
页数:29
相关论文
共 557 条
[1]
Identification of neural progenitors in the adult mammalian eye [J].
Ahmad, I ;
Tang, L ;
Pham, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 270 (02) :517-521
[2]
AHMED J, 1993, INVEST OPHTH VIS SCI, V34, P516
[3]
HYPOXIC REGULATION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR IN RETINAL CELLS [J].
AIELLO, LP ;
NORTHRUP, JM ;
KEYT, BA ;
TAKAGI, H ;
IWAMOTO, MA .
ARCHIVES OF OPHTHALMOLOGY, 1995, 113 (12) :1538-1544
[4]
Presence of mitogen-activated protein kinase in retinal Muller cells and its neuroprotective effect ischemia-reperfusion injury [J].
Akiyama, H ;
Nakazawa, T ;
Shimura, M ;
Tomita, H ;
Tamai, M .
NEUROREPORT, 2002, 13 (16) :2103-2107
[5]
Retinal gliopathy accompanying thioacetamide-induced liver insufficiency: light and electron microscopic observations [J].
Albrecht, J ;
Gadamski, R ;
Kuhrt, H ;
Walski, M ;
Reichenbach, A .
ACTA NEUROPATHOLOGICA, 1998, 96 (01) :57-66
[6]
Amin RH, 1997, INVEST OPHTH VIS SCI, V38, P36
[7]
ANDERSON DH, 1986, INVEST OPHTH VIS SCI, V27, P168
[8]
ANDERSON DR, 1975, ARCH OPHTHALMOL-CHIC, V93, P267
[9]
Andrews A, 1999, INVEST OPHTH VIS SCI, V40, P2683
[10]
THE ROLE OF JUN, FOS AND THE AP-1 COMPLEX IN CELL-PROLIFERATION AND TRANSFORMATION [J].
ANGEL, P ;
KARIN, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1072 (2-3) :129-157