Controlled assembly of peptide nanotubes triggered by enzymatic activation of self-immolative dendrimers

被引:43
作者
Adler-Abramovich, Lihi
Perry, Rotem
Sagi, Amit
Gazit, Ehud [1 ]
Shabat, Doron
机构
[1] Tel Aviv Univ, Fac Exact Sci, Sch Chem, Dept Organ Chem, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel
关键词
bionanotechnology; dendrimers; enzymatic control; molecular recognition; peptide nanotubes; self-assembly;
D O I
10.1002/cbic.200700103
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
(Chemical Equation Presented) Timed release. An AB3 self-immolative dendron has been used as a platform for the controlled release of peptide nanotubes. The enzyme penicillin G amidase triggers the release, and the self-assembled peptide is simple diphenylalanine. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:859 / 862
页数:4
相关论文
共 23 条
[1]   Thermal and chemical stability of diphenylalanine peptide nanotubes: Implications for nanotechnological applications [J].
Adler-Abramovich, L ;
Reches, M ;
Sedman, VL ;
Allen, S ;
Tendler, SJB ;
Gazit, E .
LANGMUIR, 2006, 22 (03) :1313-1320
[2]  
Amir R., 2003, Angew. Chem., V115, P4632
[3]   Self-immolative dendrimers [J].
Amir, RJ ;
Pessah, N ;
Shamis, M ;
Shabat, D .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (37) :4494-4499
[4]   Photolytic control of peptide self-assembly [J].
Bosques, CJ ;
Imperiali, B .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (25) :7530-7531
[5]   Fabrication of coaxial metal nanocables using a self-assembled peptide nanotube scaffold [J].
Carny, Ohad ;
Shalev, Deborah E. ;
Gazit, Ehud .
NANO LETTERS, 2006, 6 (08) :1594-1597
[6]   BACTERIAL PENICILLIN AMIDASE [J].
CLARIDGE, CA ;
GOUREVITCH, A ;
LEIN, J .
NATURE, 1960, 187 (4733) :237-238
[7]  
de Groot F. M. H., 2003, ANGEW CHEM, V115, P4628
[8]   Cascade-release dendrimers liberate all end groups upon a single triggering event in the dendritic core [J].
de Groot, FMH ;
Albrecht, C ;
Koekkoek, R ;
Beusker, PH ;
Scheeren, HW .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (37) :4490-4494
[9]   Switch-peptides:: Controlling self-assembly of amyloid β-derived peptides in vitro by consecutive triggering of acyl migrations [J].
Dos Santos, S ;
Chandravarkar, A ;
Mandal, B ;
Mimna, R ;
Murat, K ;
Saucède, L ;
Tella, P ;
Tuchscherer, G ;
Mutter, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (34) :11888-11889
[10]   Enzymatic activation of second-generation dendritic prodrugs: Conjugation of self-immolative dendrimers with poly(ethylene glycol) via click chemistry [J].
Gopin, Anna ;
Ebner, Sharon ;
Attali, Bernard ;
Shabat, Doron .
BIOCONJUGATE CHEMISTRY, 2006, 17 (06) :1432-1440