Acid zeolites as alcohol racemization catalysts: Screening and application in biphasic dynamic kinetic resolution

被引：74

作者：

Wuyts, S ^{[1
]}

De Temmerman, K ^{[1
]}

De Vos, DE ^{[1
]}

Jacobs, PA ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Surface Chem & Catal, B-3001 Heverlee, Belgium

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2005年 / 11卷 / 01期

关键词：

biphasic catalysis; heterogeneous catalysis; kinetic resolution; racemization; zeolites;

D O I：

10.1002/chem.200400713

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acid zeolites were screened as heterogeneous catalysts for racemization of benzylic alcohols. The most promising zeolites appeared to be H-Beta zeolites, for which the optimal reaction conditions were studied in further detail. The zeolite performance was compared to that of homogeneous acids and acid resins under similar reaction conditions. In a second part of the research, H-Beta zeolites were applied in dynamic kinetic resolution (DKR) of 1-phenylethanol, which was conducted by means of a two-phase approach and which resulted in yields smoothly crossing the 50% border up to 90%, with an enantionteric excess of >99%. To explore the applicability of this biphasic methodology, several other substrates were examined in the standard racemization reaction and in the biphasic dynamic kinetic resolution.

引用

页码：386 / 397

页数：12

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