Measuring tumor blood flow with H215O:: Practical considerations

被引:31
作者
Bacharach, SL [1 ]
Libutti, SK [1 ]
Carrasquillo, JA [1 ]
机构
[1] NCI, Ctr Clin, Bethesda, MD 20892 USA
关键词
tumor blood flow; PET; O-15-water; tumor perfusion;
D O I
10.1016/S0969-8051(00)00136-0
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The ability to measure blood flow to tumors non-invasively may be of importance in monitoring tumor therapies, assessing drug delivery, and understanding tumor physiology. Of all the radiotracer methods that have been proposed to measure tumor blood flow, the method based on labeled water-(H2O)-O-15-may be the most applicable to tumors. It is highly diffusible, does not participate significantly in metabolic processes during the short times involved in the study, and its uptake and clearance can be easily modeled. We present here an analysis of the bolus injection water methodology and how it might best be used to monitor tumor blood flow. Several different formulations of the basic methodology, based on previous applications in the heart and brain, are discussed. Potential problems of adapting these previous methodologies to tumor blood flow are presented. NUCL MED BIOL 27;7:671-676, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:671 / 676
页数:6
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