Stereocontrolled glycosylation of sordaricin in the presence of ammonium salts

被引：9

作者：

Coterón, JM

Chiara, JL

Fernández-Mayoralas, A

Fiandor, JM

Valle, N

机构：

[1] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain

[2] Glaxo Wellcome SA, PTM, Madrid 28760, Spain

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 22期

关键词：

antifungals; carbohydrates; glycosidation; stereocontrol;

D O I：

10.1016/S0040-4039(00)00654-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The glycosidation of sordaricin with deoxy sugars derivatives was studied under acid-promoted conditions and by anomeric O-alkylation with sordaricin triflate. In both methods, an important effect of added ammonium salts on the stereoselectivity of the glycosidation was observed. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：4373 / 4377

页数：5

共 16 条

[1] Stereoselective synthesis of the antifungal GM222712 [J].