Potent 3-spiropiperidine growth hormone secretagogues

被引：45

作者：

Yang, LH ^{[1
]}

Morriello, G

Prendergast, K

Cheng, K

Jacks, T

Chan, WWS

Schleim, KD

Smith, RG

Patchett, AA

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Physiol & Biochem, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(97)10199-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4'-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3'-piperidine) was found to afford secretagogues with low nanomolar in vitro activity. (C) 1997 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：107 / 112

页数：6

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