A facile synthesis of polysubstituted pyrroles

被引：106

作者：

Dieter, RK ^{[1
]}

Yu, HY ^{[1
]}

机构：

[1] Clemson Univ, Howard L Hunter Chem Lab, Clemson, SC 29634 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 15期

关键词：

D O I：

10.1021/ol006050q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] alpha-Aminoalkylcuprates prepared from CUX . SLiCl (X = Cl, CN) and 1 equiv of an alpha-lithiocarbamate undergo conjugate addition reactions to alpha,beta-alkynyl ketones in moderate to good yields, affording E:Z mixtures of alpha,beta-enones. Treatment of the conjugate adducts with PhOH/TMSCl in CH2Cl2, effected carbamate deprotection and cyclization to afford a flexible two-step synthesis of substituted pyrroles.

引用

页码：2283 / 2286

页数：4

共 51 条

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