A facile synthesis of polysubstituted pyrroles

被引:106
作者
Dieter, RK [1 ]
Yu, HY [1 ]
机构
[1] Clemson Univ, Howard L Hunter Chem Lab, Clemson, SC 29634 USA
关键词
D O I
10.1021/ol006050q
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] alpha-Aminoalkylcuprates prepared from CUX . SLiCl (X = Cl, CN) and 1 equiv of an alpha-lithiocarbamate undergo conjugate addition reactions to alpha,beta-alkynyl ketones in moderate to good yields, affording E:Z mixtures of alpha,beta-enones. Treatment of the conjugate adducts with PhOH/TMSCl in CH2Cl2, effected carbamate deprotection and cyclization to afford a flexible two-step synthesis of substituted pyrroles.
引用
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页码:2283 / 2286
页数:4
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