Biological effects of casein-derived tripeptide powders are not affected by fermentation process

被引：9

作者：

Jakala, Pauliina ^{[1
]}

Turpeinen, Anu M. ^{[2
]}

Rajakari, Kirsi ^{[2
]}

Korpela, Riitta ^{[1
,2
]}

Vapaatalo, Heikki ^{[1
]}

机构：

[1] Univ Helsinki, Inst Biomed, FIN-00014 Helsinki, Finland

[2] Valio Ltd, R&D, Valio 00039, Finland

来源：

INTERNATIONAL DAIRY JOURNAL | 2010年 / 20卷 / 05期

关键词：

SPONTANEOUSLY HYPERTENSIVE-RATS; LONG-TERM INTAKE; NORMAL BLOOD-PRESSURE; I-CONVERTING-ENZYME; LACTOBACILLUS-HELVETICUS; BIOACTIVE PEPTIDES; MILD HYPERTENSION; NITRIC-OXIDE; SOUR MILK; ASSAY;

D O I：

10.1016/j.idairyj.2009.11.017

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Milk casein-derived biologically active tripeptides isoleucine-proline-proline and valine-proline-proline have shown antihypertensive effects both in animal and clinical studies. Contradictory findings from clinical intervention studies may be related to different manufacturing processes. The present study aimed to compare cardiovascular effects of two different tripeptide powders in spontaneously hypertensive rat (SHR). Rats received tripeptide powders produced either by Lactobacillus helveticus fermentation (A) or Lb. helveticus plus proline specific endoprotease (B) in drinking fluid for 8 weeks. Systolic blood pressure was recorded weekly. At the end, blood and tissue samples were collected and arterial responses studied. Blood pressure was 13.6 and 14.2 mmHg lower in the groups A and B, respectively, versus the water group (P < 0.01). Vascular responses of aorta and mesenteric artery did not differ between the groups. Both tripeptide products increased urinary cGMP (P < 0.001) and decreased albumin (P < 0.05). The fermentation process did not influence the cardiovascular effects of the tripeptide powders. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：366 / 370

页数：5

共 30 条

[1]

Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high-normal blood pressure or mild hypertension [J].

Aihara, K ;

Kajimoto, O ;

Hirata, H ;

Takahashi, R ;

Nakamura, Y .

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2005, 24 (04) :257-265

[2]

Protective effects of the angiotensin II type I (ATl) receptor blockade in low-renin deoxycorticosterone acetate (DOCA)-treated spontaneously hypertensive rats [J].

Chamorro, V ;

Wangensteen, R ;

Sainz, J ;

Duarte, J ;

O'Valle, F ;

Osuna, A ;

Vargas, F .

CLINICAL SCIENCE, 2004, 106 (03) :251-259

[3]

Peptidases and amino acid catabolism in lactic acid bacteria [J].

Christensen, JE ;

Dudley, EG ;

Pederson, JA ;

Steele, JL .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1999, 76 (1-4) :217-246

[4]

Potential uses of caseinophosphopeptides [J].

FitzGerald, RJ .

INTERNATIONAL DAIRY JOURNAL, 1998, 8 (5-6) :451-457

[5]

Endothelial nitric oxide synthase in vascular disease -: From marvel to menace [J].

Förstermann, U ;

Münzel, T .

CIRCULATION, 2006, 113 (13) :1708-1714

[6]

Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle [J].

Husson, A ;

Brasse-Lagnel, C ;

Fairand, A ;

Renouf, S ;

Lavoinne, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2003, 270 (09) :1887-1899

[7]

Milk protein-derived bioactive tripeptides Ile-Pro-Pro and Val-Pro-Pro protect endothelial function in vitro in hypertensive rats [J].

Jakala, Pauliina ;

Jauhiainen, Tiina ;

Korpela, Riitta ;

Vapaatalo, Heikki .

JOURNAL OF FUNCTIONAL FOODS, 2009, 1 (03) :266-273

[8]

Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement [J].

Jauhiainen, T ;

Vapaatalo, H ;

Poussa, T ;

Kyrönpalo, S ;

Rasmussen, M ;

Korpela, R .

AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (12) :1600-1605

[9]

Jauhiainen T, 2005, MILCHWISSENSCHAFT, V60, P358

[10]

Maternal supplementation with citrulline increases renal nitric oxide in young spontaneously hypertensive rats and has long-term antihypertensive effects [J].

Koeners, Maarten P. ;

van Faassen, Ernst E. ;

Wesseling, Sebastiaan ;

de Sain-van der Velden, Monique ;

Koomans, Hein A. ;

Braam, Branko ;

Joles, Jaap A. .

HYPERTENSION, 2007, 50 (06) :1077-1084

← 1 2 3 →