Synthesis and transformations of methyl (E)-2-(acetylamino)-3-cyanoprop-2-enoate und methyl (E)-2-(benzoylamino)-3-cyanoprop-2-enoate, versatile reagents for the preparation of polyfunctional heterocyclic systems

被引：37

作者：

Pizzioli, L ^{[1
]}

Ornik, B ^{[1
]}

Svete, J ^{[1
]}

Stanovnik, B ^{[1
]}

机构：

[1] Univ Ljubljana, Dept Chem & Chem Technol, Ljubljana 1000, Slovenia

来源：

HELVETICA CHIMICA ACTA | 1998年 / 81卷 / 02期

关键词：

D O I：

10.1002/hlca.19980810205

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methyl (E)-2-(acetylamino)-3-cyanoprop-2-enoate (2a) and its 2-benzoyl analog 2b were prepared from the corresponding methyl (Z)-2-(acylamino)-3-(dimethylamino)propenoates 1. Multifunctional compounds Z are versatile synthons for preparation of polysubstituted heterocyclic systems such as pyrroles 4, pyrimidines 5 and 6, pyridazines 7, pyrazoles 8, 9, and 11, and isoxazoles 10.

引用

页码：231 / 235

页数：5

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