Genetic initiation of hypertensive and diabetic nephropathy

被引：24

作者：

Freedman, BI

Bowden, DW

Rich, SS

Appel, RG

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med Nephrol, Winston Salem, NC 27157 USA

[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA

[3] Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27157 USA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1998年 / 11卷 / 02期

关键词：

diabetic nephropathy; hypertensive nephrosclerosis; blacks; genetic linkage analysis;

D O I：

10.1016/S0895-7061(97)00481-0

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The factors initiating the common etiologies of chronic renal failure remain elusive. This article reviews the evidence in support of a generalized genetic susceptibility to human end-stage renal disease, including kidney failure attributed to the systemic diseases of hypertension, diabetes mellitus, and glomerulonephritis. Molecular genetic techniques are powerful tools, assisting in the detection of the initiating factors in many complex diseases. In kidney disease, genetic methodologies complement the available anatomic, epidemiologic, and physiologic analyses. This article provides strategies to allow for the detection of human renal failure susceptibility genes. The identification of human renal failure genes would provide useful markers for disease susceptibility and speed the development of novel therapeutic strategies. (C) 1998 American Journal of Hypertension, Ltd.

引用

页码：251 / 257

页数：7

共 54 条

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