The catalytic mechanism of nucleoside diphosphate kinases

被引：165

作者：

Lascu, I ^{[1
]}

Gonin, P

机构：

[1] Univ Bordeaux 2, Inst Biochim & Genet Cellulaires, UMR 5095, F-33077 Bordeaux, France

[2] CNRS, F-33077 Bordeaux, France

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2000年 / 32卷 / 03期

关键词：

NDP kinase; ping-pong mechanism; phosphohistidine; substrate-assisted catalysis; nucleotide analog;

D O I：

10.1023/A:1005532912212

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Nucleoside diphosphate kinases catalyze the reversible transfer of the gamma phosphate of nucleoside triphosphates to nucleoside diphosphates. This minireview presents recent advances in understanding the reaction mechanism using steady-state and fast kinetic studies, X-ray crystallography, and site-directed mutagenesis. We also briefly discuss the physiological relevance of in vitro studies.

引用

页码：237 / 246

页数：10

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