Imatinib plasma levels: correlation with clinical benefit in GIST patients

被引:36
作者
Widmer, N. [1 ,2 ]
Decosterd, L. A. [1 ,2 ]
Csajka, C. [1 ,2 ]
Montemurro, M. [3 ]
Haouala, A. [1 ,2 ]
Leyvraz, S. [3 ]
Buclin, T. [1 ,2 ]
机构
[1] CHU Vaudois, Div Clin Pharmacol & Toxicol, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne, Hop Beaumont 06 605, CH-1011 Lausanne, Switzerland
[3] CHU Vaudois, Multidisciplinary Oncol Ctr, CH-1011 Lausanne, Switzerland
关键词
GASTROINTESTINAL STROMAL TUMORS; CHRONIC MYELOID-LEUKEMIA; PHARMACOKINETICS;
D O I
10.1038/sj.bjc.6605584
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1198 / 1199
页数:2
相关论文
共 10 条
[1]   Therapeutic drug monitoring in CML patients on imatinib [J].
Blasdel, Carolyn ;
Egorin, Merrill J. ;
Lagattuta, Theodore F. ;
Druker, Brian J. ;
Deininger, Michael W. .
BLOOD, 2007, 110 (05) :1699-1701
[2]   Pharmacokinetic-pharmacodynamic relationships of imatinib and its main metabolite in patients with advanced gastrointestinal stromal tumors [J].
Delbaldo, Catherine ;
Chatelut, Etienne ;
Re, Micheline ;
Deroussent, Alain ;
Seronie-Vivien, Sophie ;
Jambu, Aurore ;
Berthaud, Patrice ;
Le Cesne, Axel ;
Blay, Jean-Yves ;
Vassal, Gilles .
CLINICAL CANCER RESEARCH, 2006, 12 (20) :6073-6078
[3]   Imatinib Plasma Levels Are Correlated With Clinical Benefit in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors [J].
Demetri, George D. ;
Wang, Yanfeng ;
Wehrle, Elisabeth ;
Racine, Amy ;
Nikolova, Zariana ;
Blanke, Charles D. ;
Joensuu, Heikki ;
von Mehren, Margaret .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (19) :3141-3147
[4]   Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry [J].
Haouala, A. ;
Zanolari, B. ;
Rochat, B. ;
Montemurro, M. ;
Zaman, K. ;
Duchosal, M. A. ;
Ris, H. B. ;
Leyvraz, S. ;
Widmer, N. ;
Decosterd, L. A. .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2009, 877 (22) :1982-1996
[5]   Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor [J].
Heinrich, MC ;
Corless, CL ;
Demetri, GD ;
Blanke, CD ;
von Mehren, M ;
Joensuu, H ;
McGreevey, LS ;
Chen, CJ ;
Van den Abbeele, AD ;
Druker, BJ ;
Kiese, B ;
Eisenberg, B ;
Roberts, PJ ;
Singer, S ;
Fletcher, CDM ;
Silberman, S ;
Dimitrijevic, S ;
Fletcher, JA .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (23) :4342-4349
[6]   Imatinib pharmacokinetics in patients with gastrointestinal stromal tumour: a retrospective population pharmacokinetic study over time. EORTC Soft Tissue and Bone Sarcoma Group [J].
Judson, I ;
Ma, PM ;
Peng, B ;
Verweij, J ;
Racine, A ;
di Paola, FD ;
van Glabbeke, M ;
Dimitrijevic, S ;
Scurr, M ;
Dumez, H ;
van Oosterom, A .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2005, 55 (04) :379-386
[7]   Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study [J].
Larson, Richard A. ;
Druker, Brian J. ;
Guilhot, Francois ;
O'Brien, Stephen G. ;
Riviere, Gilles J. ;
Krahnke, Tillmann ;
Gathmann, Insa ;
Wang, Yanfeng .
BLOOD, 2008, 111 (08) :4022-4028
[8]   Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia [J].
Picard, Stephane ;
Titier, Karine ;
Etienne, Gabriel ;
Teilhet, Ernmanuelle ;
Ducint, Dominique ;
Bernard, Marie-Agnes ;
Lassalle, Regis ;
Marit, Gerald ;
Reiffers, Josy ;
Begaud, Bernard ;
Moore, Nicholas ;
Molimard, Mathieu ;
Mahon, Francois-Xavier .
BLOOD, 2007, 109 (08) :3496-3499
[9]   Relationship of imatinib-free plasma levels and target genotype with efficacy and tolerability [J].
Widmer, N. ;
Decosterd, L. A. ;
Leyvraz, S. ;
Duchosal, M. A. ;
Rosselet, A. ;
Debiec-Rychter, M. ;
Csajka, C. ;
Biollaz, J. ;
Buclin, T. .
BRITISH JOURNAL OF CANCER, 2008, 98 (10) :1633-1640
[10]   Population pharmacokinetics of imatinib and the role of α1-acid glycoprotein [J].
Widmer, N. ;
Decosterd, L. A. ;
Csajka, C. ;
Leyvraz, S. ;
Duchosal, M. A. ;
Rosselet, A. ;
Rochat, B. ;
Eap, C. B. ;
Henry, H. ;
Biollaz, J. ;
Buclin, T. .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 62 (01) :97-112