Prevention of atherosclerosis with dietary antioxidants: Fact or fiction?

被引:26
作者
Duell, PB
机构
关键词
antioxidants; vitamins; atherosclerosis; low density lipoprotein (LDL); diet;
D O I
10.1093/jn/126.suppl_4.1067S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The notion that oxidation of lipids and lipoproteins may contribute to the pathogenesis of atherosclerosis is supported by a large body of evidence. It is hypothesized that dietary antioxidants may help prevent development and progression of atherosclerosis. The available evidence helps substantiate this hypothesis but is not yet conclusive. The results of several ongoing large randomized intervention trials will provide valuable information about the efficacy and safety of supplemental dietary antioxidants in prevention of atherosclerosis.
引用
收藏
页码:S1067 / S1071
页数:5
相关论文
共 38 条
[1]  
[Anonymous], FREE RADICALS AGING
[2]   PATIENTS WITH EARLY-ONSET PERIPHERAL VASCULAR-DISEASE HAVE INCREASED LEVELS OF AUTOANTIBODIES AGAINST OXIDIZED LDL [J].
BERGMARK, C ;
WU, R ;
DEFAIRE, U ;
LEFVERT, AK ;
SWEDENBORG, J .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (04) :441-445
[3]   NUTRITION INTERVENTION TRIALS IN LINXIAN, CHINA - SUPPLEMENTATION WITH SPECIFIC VITAMIN MINERAL COMBINATIONS, CANCER INCIDENCE, AND DISEASE-SPECIFIC MORTALITY IN THE GENERAL-POPULATION [J].
BLOT, WJ ;
LI, JY ;
TAYLOR, PR ;
GUO, WD ;
DAWSEY, S ;
WANG, GQ ;
YANG, CS ;
ZHENG, SF ;
GAIL, M ;
LI, GY ;
YU, Y ;
LIU, BQ ;
TANGREA, J ;
SUN, YH ;
LIU, FS ;
FRAUMENI, JF ;
ZHANG, YH ;
LI, B .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (18) :1483-1492
[4]  
BOLTONSMITH C, 1992, EUR J CLIN NUTR, V46, P85
[5]   FLAVONOIDS INHIBIT THE OXIDATIVE MODIFICATION OF LOW-DENSITY LIPOPROTEINS BY MACROPHAGES [J].
DEWHALLEY, CV ;
RANKIN, SM ;
HOULT, JRS ;
JESSUP, W ;
LEAKE, DS .
BIOCHEMICAL PHARMACOLOGY, 1990, 39 (11) :1743-1750
[6]   THE ROLE OF DIETARY ANTIOXIDANTS IN PREVENTION OF ATHEROSCLEROSIS [J].
DUELL, PB .
ENDOCRINOLOGIST, 1995, 5 (05) :347-356
[7]  
DUELL PB, 1994, CURR OPIN ENDOCRINOL, V1, P251
[8]   INHIBITION OF OXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN BY PHENOLIC SUBSTANCES IN RED WINE [J].
FRANKEL, EN ;
KANNER, J ;
GERMAN, JB ;
PARKS, E ;
KINSELLA, JE .
LANCET, 1993, 341 (8843) :454-457
[9]   USE OF CROCETIN IN EXPERIMENTAL ATHEROSCLEROSIS [J].
GAINER, JL ;
JONES, JR .
EXPERIENTIA, 1975, 31 (05) :548-549
[10]   SUPPLEMENTATION WITH BETA-CAROTENE IN-VIVO AND IN-VITRO DOES NOT INHIBIT LOW-DENSITY-LIPOPROTEIN OXIDATION [J].
GAZIANO, JM ;
HATTA, A ;
FLYNN, M ;
JOHNSON, EJ ;
KRINSKY, NI ;
RIDKER, PM ;
HENNEKENS, CH ;
FREI, B .
ATHEROSCLEROSIS, 1995, 112 (02) :187-195