Ring expansion of N-acyl aziridine-2-imides to oxazoline-4-imides, useful precursors of pure beta-hydroxy alpha-aminoacids.

被引：39

作者：

Cardillo, G ^{[1
]}

Gentilucci, L ^{[1
]}

Tolomelli, A ^{[1
]}

Tomasini, C ^{[1
]}

机构：

[1] UNIV BOLOGNA,CSFM,CNR,I-40126 BOLOGNA,ITALY

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(97)01630-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active N-acyl aziridine P-imides or 2-carboxylates rearrange to oxazoline-4-imides or 4-carboxylates with high regio and stereo control. This ring expansion followed by mild hydrolisis allows the synthesis of enantiomerically pure beta-hydroxy alpha-aminoacid precursors. (C) 1997 Published by Elsevier Science Ltd.

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页码：6953 / 6956

页数：4

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