Signaling networks linking integrins and Rho family GTPases

被引：256

作者：

Schwartz, MA ^{[1
]}

Shattil, SJ

机构：

[1] Scripps Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(00)01605-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Integrins and Rho family GTPases function coordinately to mediate adhesion-dependent events in cells, Recently, it has also become apparent that integrins regulate Rho GTPases and vice versa, Integrins and GTPases might therefore be organized into complex signaling cascades that regulate cell behavior.

引用

页码：388 / 391

页数：4

共 50 条

[1]

Aepfelbacher M, 1996, J IMMUNOL, V157, P5070

[2] Requirement for Rho in integrin signalling [J].

Barry, ST ;

Flinn, HM ;

Humphries, MJ ;

Critchley, DR ;

Ridley, AJ .

CELL ADHESION AND COMMUNICATION, 1996, 4 (06) :387-398

[3] Are changes in integrin affinity and conformation overemphasized? [J].

Bazzoni, G ;

Hemler, ME .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (01) :30-34

[4] Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13 [J].

Bloom, L ;

Ingham, KC ;

Hynes, RO .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (05) :1521-1536

[5] Focal adhesions, contractility, and signaling [J].

Burridge, K ;

ChrzanowskaWodnicka, M .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :463-518

[6]

Cary LA, 1999, HISTOL HISTOPATHOL, V14, P1001, DOI 10.14670/HH-14.1001

[7] Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells [J].

Cheresh, DA ;

Leng, J ;

Klemke, RL .

JOURNAL OF CELL BIOLOGY, 1999, 146 (05) :1107-1116

[8] THE SMALL GTP-BINDING PROTEIN-RHO REGULATES A PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE IN MAMMALIAN-CELLS [J].

CHONG, LD ;

TRAYNORKAPLAN, A ;

BOKOCH, GM ;

SCHWARTZ, MA .

CELL, 1994, 79 (03) :507-513

[9] Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95(vav), in platelets [J].

Cichowski, K ;

Brugge, JS ;

Brass, LF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) :7544-7550

[10] Integrin-mediated signals regulated by members of the Rho family of GTPases [J].

Clark, EA ;

King, WG ;

Brugge, JS ;

Symons, M ;

Hynes, RO .

JOURNAL OF CELL BIOLOGY, 1998, 142 (02) :573-586

← 1 2 3 4 5 →