Self-assembled nanostructures from peptide-synthetic hybrid block copolymers: Complex, stimuli-responsive rod-coil architectures

被引：84

作者：

Babin, J

Rodriguez-Hernandez, J

Lecommandoux, S

Klok, HA

Achard, MF

机构：

[1] Univ Bordeaux 1, CNRS, ENSCPB, Lab Chim Polymeres Organ, F-33607 Pessac, France

[2] Ecole Polytech Fed Lausanne, Inst Mat, Lab Polymeres, CH-1015 Lausanne, Switzerland

[3] Univ Bordeaux 1, CNRS, Ctr Rech Paul Pascal, F-33607 Pessac, France

来源：

FARADAY DISCUSSIONS | 2005年 / 128卷

关键词：

D O I：

10.1039/b403203a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The synthesis, solution and solid state self-assembly properties of a series of polyisoprene-b-poly(epsilon-benzyloxycarbonyl-L-lysine) PI-b-PZLys and polyisoprene-b-poly(L-lysine) PI-b-PLys block copolymers have been examined. The formation of stimuli-responsive micelles in water has been studied as a function of pH and ionic strength using static and dynamic light scattering, UV-circular dichroism and transmission electron microscopy. The observed change in the micelles dimensions has been directly attributed to the conformational transition in the secondary structure of polypeptide chains. In bulk, these rod-coil copolymers form self-assembled structures that have been characterized using DSC, DMA, WAXS and SAXS techniques. Hexagonal in lamellar (HL) and more interestingly hexagonal in hexagonal (HH) morphologies have been evidenced as a function of the chemical composition.

引用

页码：179 / 192

页数：14

共 44 条

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