Single-Neuron Responses in Humans during Execution and Observation of Actions

被引:734
作者
Mukamel, Roy [1 ,2 ,3 ]
Ekstrom, Arne D. [1 ,5 ]
Kaplan, Jonas [2 ,3 ,6 ,7 ]
Iacoboni, Marco [2 ,3 ,4 ]
Fried, Itzhak [1 ,3 ,4 ,8 ,9 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA
[5] Univ Calif Davis, Ctr Neurosci, Davis, CA 95618 USA
[6] Univ So Calif, Brain & Creat Inst, Los Angeles, CA 90098 USA
[7] Univ So Calif, Dept Psychol, Los Angeles, CA 90098 USA
[8] Tel Aviv Univ, Funct Neurosurg Unit, Tel Aviv Med Ctr, IL-69978 Tel Aviv, Israel
[9] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
基金
美国国家卫生研究院;
关键词
MIRROR NEURONS; PREMOTOR CORTEX; MONKEY; MOTOR; REPRESENTATION; PARCELLATION; RECOGNITION; EXPERIENCE; IMITATION;
D O I
10.1016/j.cub.2010.02.045
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Direct recordings in monkeys have demonstrated that neurons in frontal and parietal areas discharge during execution and perception of actions [1-8]. Because these discharges "reflect" the perceptual aspects of actions of others onto the motor repertoire of the perceiver, these cells have been called mirror neurons. Their overlapping sensory-motor representations have been implicated in observational learning and imitation, two important forms of learning [9]. In humans, indirect measures of neural activity support the existence of sensory-motor mirroring mechanisms in homolog frontal and parietal areas [10,11], other motor regions [12-15], and also the existence of multisensory mirroring mechanisms in nonmotor regions [16-19]. We recorded extracellular activity from 1177 cells in human medial frontal and temporal cortices while patients executed or observed hand grasping actions and facial emotional expressions. A significant proportion of neurons in supplementary motor area, and hippocampus and environs, responded to both observation and execution of these actions. A subset of these neurons demonstrated excitation during action-execution and inhibition during action-observation. These findings suggest that multiple systems in humans may be endowed with neural mechanisms of mirroring for both the integration and differentiation of perceptual and motor aspects of actions performed by self and others.
引用
收藏
页码:750 / 756
页数:7
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