The copper complex of captopril is not a superoxide dismutase mimic. Artefacts in DMPO spin trapping

被引：10

作者：

Bartosz, M

Kedziora, J

Bartosz, G

机构：

[1] UNIV LODZ,DEPT MOLEC BIOPHYS,PL-902237 LODZ,POLAND

[2] MIL MED UNIV,INST FUNDAMENTAL SCI,DEPT PHYSIOL,PL-90647 LODZ,POLAND

来源：

FREE RADICAL RESEARCH | 1996年 / 24卷 / 05期

关键词：

captopril; superoxide radical; copper; superoxide dismutase; SOD-mimics;

D O I：

10.3109/10715769609088037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of captopril and of its copper complex on several superoxide-dependent reactions used to detect and assay superoxide dismutase activity was studied, including pyrogallol and hematoxylin autoxidation and Nitro Blue Tetrazolium reduction. In none of these systems were superoxide dismutase-like properties of captopril/Cu apparent. Captopril/Cu decreased the yield of DMPO-OH adducts generated by KO2 but this effect may be due to the acceleration of the decay of the adduct by captopril/Cu.

引用

页码：391 / 396

页数：6

共 14 条

[1]

ANTONACCIO MJ, 1981, FED PROC, V40, P2275

[2] EVALUATION OF THE ABILITY OF THE ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR CAPTOPRIL TO SCAVENGE REACTIVE OXYGEN SPECIES [J].