Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems

被引：89

作者：

Medina, DL ^{[1
]}

Santisteban, P ^{[1
]}

机构：

[1] UAM, CSIC, Inst Invest Biomed Alberto Sols, E-28029 Madrid, Spain

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2000年 / 143卷 / 02期

关键词：

D O I：

10.1530/eje.0.1430161

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review is focused on the most recent knowledge on growth control of rat thyroid cell lines. Mie analyzed the effect of mitogenic as well as inhibitory agents, but mainly the proliferative effect elicited by thyrotropin (TSH). The classic cAMP-dependent protein kinase (PKA) signal transduction pathway involved in TSH-mediated cell growth is analyzed exhaustively We have also reviewed new concepts about the participation of other effecters such as small GTPases and phosphatidyl inositol-3-kinase (PI3-K) and the new data about the existence of a cAMP-dependent but PKA-independent pathway. Finally, we give information about TSH induction of cell cycle-related genes, such as G1 cyclins, cyclin-dependent kinases (CDEs) and CDK inhibitors.

引用

页码：161 / 178

页数：18

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