Decreased TCR ζ-chain expression in T cells from patients with acquired aplastic anaemia

被引：15

作者：

Solomou, Elena E.

Wong, Susan

Visconte, Valeria

Gibellini, Federica

Young, Neal S.

机构：

[1] Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD

[2] NIH, Hematology Branch, Building 10, Bethesda, MD 20892

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 138卷 / 01期

关键词：

aplastic anaemia; T cells; bone marrow failure;

D O I：

10.1111/j.1365-2141.2007.06627.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In aplastic anaemia, T cells have a central role in the pathophysiology of bone marrow destruction. This study showed that T cells from patients with aplastic anaemia expressed decreased T-cell receptor (TCR) zeta-chain protein and mRNA levels compared to healthy controls. Patients with decreased TCR zeta-chain showed an abnormal response in intracellular calcium following stimulation through the TCR. We also observed an altered pattern of the transcription factors CREM alpha and Elf-1 that are implicated in zeta-chain transcription. We concluded that TCR zeta-chain expression was decreased in the majority of patients with aplastic anaemia, regardless of disease activity or treatment status.

引用

页码：72 / 76

页数：5

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