Recurrent mossy fibers preferentially innervate parvalbumin-immunoreactive interneurons in the granule cell layer of the rat dentate gyrus

被引:22
作者
Blasco-Ibáñez, JM
Martínez-Guijarro, FJ
Freund, TF
机构
[1] Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary
[2] Univ Valencia, Fac Biol, Dept Cell Biol, E-46100 Burjassot, Spain
关键词
basket cell; dentate gyrus; granule cells; hippocampus; mossy fibers; Zn detection;
D O I
10.1097/00001756-200009280-00034
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Detection of vesicular zinc and immunohistochemistry against markers for different interneuron subsets were combined to study the postsynaptic target selection of zinc-containing recurrent mossy fiber collaterals in the dentate gyrus. Mossy fiber collaterals in the granule cell layer selectively innervated parvalbumin-containing cells, with numerous contacts per cell, whereas the granule cells were avoided. Under the electron microscope, those boutons made asymmetrical contacts on dendrites and somata. These findings suggest that, in addition to the hilar perforant path-associated (HIPP) interneurons, the basket and chandelier cells also receive a powerful feed-back drive from the granule cells, and thereby are able to control population synchrony in the dentate gyrus. On the other hand, the amount of monosynaptic excitatory feed-back among granule cells is shown to be negligible. NeuroReport 11:3219-3225 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:3219 / 3225
页数:7
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