Mechanisms that prevent and produce double ovulations in dairy cattle

被引:108
作者
Wiltbank, MC [1 ]
Fricke, PM
Sangsritavong, S
Sartori, R
Ginther, OJ
机构
[1] Univ Wisconsin, Endocrinol Reprod Physiol Program, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Dairy Sci, Madison, WI 53706 USA
关键词
follicle; twinning; double ovulation; reproduction;
D O I
10.3168/jds.S0022-0302(00)75201-5
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
This review integrates information on follicular and hormonal physiology and epidemiology into a novel physiological model for regulation of the ovulation rate in lactating dairy cows. First, the basic mechanisms that produce a single ovulation are examined. Follicular deviation is a critical new concept in our understanding of selection of a single dominant follicle. Follicular deviation is characterized by an abrupt deviation in the growth rates between the two largest follicles when the future dominant follicle reaches a diameter of 8.5 +/- 1.2 mm (mean and SD). The mechanisms involved in this selection process are not completely defined but appear to involve acquisition of LH receptors on granulosa cells of the dominant follicle, increased estradiol production by the dominant follicle, and inhibition of circulating FSH concentrations. Second, lactation number and milk production were found to be critical epidemiological factors associated with increased ovulation rate and twinning in dairy cattle. Finally, high steroid metabolism is proposed as the critical link between high milk production and double ovulation. It is proposed that high milk production increases steroid metabolism due to increased blood flow to the digestive tract and subsequently to the liver. The liver represents the primary site of steroid metabolism, and blood entering the liver is cleared of steroids. At the time of selection of the dominant follicle, the normal increase in circulating estradiol concentrations and subsequent depression in circulating FSH is blunted due to estradiol metabolism. Thus, FSH remains elevated for a time sufficient to allow follicles to undergo the physiological changes necessary to proceed to ovulation.
引用
收藏
页码:2998 / 3007
页数:10
相关论文
共 78 条
[1]  
ADAMS GP, 1992, J REPROD FERTIL, V94, P177, DOI 10.1530/jrf.0.0940177
[2]   INDUCTION OF TWINS IN CATTLE WITH BILATERAL AND UNILATERAL EMBRYO TRANSFER [J].
ANDERSON, GB ;
CUPPS, PT ;
DROST, M .
JOURNAL OF ANIMAL SCIENCE, 1979, 49 (04) :1037-1042
[3]  
[Anonymous], 1920, J DAIRY SCI, DOI DOI 10.3168/JDS.S0022-0302(20)94273-X
[4]  
[Anonymous], DTSCH TIERIRZGL WSCH
[5]   THE USE OF A MODIFIED BROMOSULFTHALEIN EXCRETION TEST FOR THE MEASUREMENT OF HEPATIC BLOOD-FLOW IN CALVES [J].
ARAYA, O ;
FORD, EJH .
QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1982, 67 (04) :513-519
[6]  
Armstrong D G, 1997, Rev Reprod, V2, P139, DOI 10.1530/ror.0.0020139
[7]  
Bao B, 1998, J ANIM SCI, V76, P1903
[8]   THE ECONOMICS OF NATURALLY-OCCURRING TWINNING IN DAIRY-CATTLE [J].
BEEREPOOT, GMM ;
DYKHUIZEN, AA ;
NIELEN, M ;
SCHUKKEN, YH .
JOURNAL OF DAIRY SCIENCE, 1992, 75 (04) :1044-1051
[9]  
Berry S. L., 1994, Journal of Dairy Science, V77, P379
[10]   Alterations in follicular estradiol and gonadotropin receptors during development of bovine antral follicles [J].
Bodensteiner, KJ ;
Wiltbank, MC ;
Bergfelt, DR ;
Ginther, OJ .
THERIOGENOLOGY, 1996, 45 (02) :499-512