Defective melanocortin 4 receptors in hyperphagia and morbid obesity

被引:30
作者
List, JF [1 ]
Habener, JF [1 ]
机构
[1] Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA
关键词
D O I
10.1056/NEJMe030013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1160 / 1163
页数:4
相关论文
共 15 条
[1]   Binge eating as a major phenotype of melanocortin 4 receptor gene mutations [J].
Branson, R ;
Potoczna, N ;
Kral, JG ;
Lentes, K ;
Hoehe, MR ;
Horber, FF .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1096-1103
[2]   An empirical study of the classification of eating disorders [J].
Bulik, CM ;
Sullivan, PF ;
Kendler, KS .
AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (06) :886-895
[3]  
Chen DL, 1999, J LIPID RES, V40, P1735
[4]  
del Giudice EM, 2002, INT J OBESITY, V26, P647, DOI [10.1038/sj.ijo.0801983, 10.1038/sj/ijo/0801983]
[5]   Binge eating disorder: a review [J].
Dingemans, AE ;
Bruna, MJ ;
van Furth, EF .
INTERNATIONAL JOURNAL OF OBESITY, 2002, 26 (03) :299-307
[6]   Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene [J].
Farooqi, IS ;
Keogh, JM ;
Yeo, GSH ;
Lank, EJ ;
Cheetham, T ;
O'Rahilly, S .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1085-1095
[7]   Identification and functional analysis of novel human melanocortin-4 receptor variants [J].
Gu, W ;
Tu, ZM ;
Kleyn, PW ;
Kissebah, A ;
Duprat, L ;
Lee, J ;
Chin, W ;
Maruti, S ;
Deng, NH ;
Fisher, SL ;
Franco, LS ;
Burn, P ;
Yagaloff, KA ;
Nathan, J ;
Heymsfield, S ;
Albu, J ;
Pi-Sunyer, FX ;
Allison, DB .
DIABETES, 1999, 48 (03) :635-639
[8]   Targeted disruption of the melanocortin-4 receptor results in obesity in mice [J].
Huszar, D ;
Lynch, CA ;
FairchildHuntress, V ;
Dunmore, JH ;
Fang, Q ;
Berkemeier, LR ;
Gu, W ;
Kesterson, RA ;
Boston, BA ;
Cone, RD ;
Smith, FJ ;
Campfield, LA ;
Burn, P ;
Lee, F .
CELL, 1997, 88 (01) :131-141
[9]   Melanocortin 4 receptor sequence variations are seldom a cause of human obesity:: The Swedish obese subjects, the HERITAGE family study, and a Memphis cohort [J].
Jacobson, P ;
Ukkola, O ;
Rankinen, T ;
Snyder, EE ;
Leon, AS ;
Rao, DC ;
Skinner, JS ;
Wilmore, JH ;
Lönn, L ;
Cowan, GS ;
Sjöström, L ;
Bouchard, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (10) :4442-4446
[10]   Genetic and environmental factors in relative body weight and human adiposity [J].
Maes, HHM ;
Neale, MC ;
Eaves, LJ .
BEHAVIOR GENETICS, 1997, 27 (04) :325-351