Signal transduction - Lipid rafts and insulin action

被引：31

作者：

Czech, MP

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Worcester, MA 01605 USA

来源：

NATURE | 2000年 / 407卷 / 6801期

关键词：

D O I：

10.1038/35025183

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Insulin works by encouraging muscle and fat cells to take up glucose from blood. One intracellular signalling pathway that is stimulated by insulin is known. Another has now been identified.

引用

页码：147 / 148

页数：2

共 10 条

[1] ALTERNATIVE PATHWAY OF INSULIN SIGNALING IN MICE WITH TARGETED DISRUPTION OF THE IRS-1 GENE [J].

ARAKI, E ;

LIPES, MA ;

PATTI, ME ;

BRUNING, JC ;

HAAG, B ;

JOHNSON, RS ;

KAHN, CR .

NATURE, 1994, 372 (6502) :186-190

[2] CAP defines a second signalling pathway required for insulin-stimulated glucose transport [J].

Baumann, CA ;

Ribon, V ;

Kanzaki, M ;

Thurmond, DC ;

Mora, S ;

Shigematsu, S ;

Bickel, PE ;

Pessin, JE ;

Saltiel, AR .

NATURE, 2000, 407 (6801) :202-207

[3] PHOSPHATIDYLINOSITOL 3-KINASE ACTIVATION IS REQUIRED FOR INSULIN STIMULATION OF PP70 S6 KINASE, DNA-SYNTHESIS, AND GLUCOSE-TRANSPORTER TRANSLOCATION [J].

CHEATHAM, B ;

VLAHOS, CJ ;

CHEATHAM, L ;

WANG, L ;

BLENIS, J ;

KAHN, CR .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) :4902-4911

[4] Signaling mechanisms that regulate glucose transport [J].

Czech, MP ;

Corvera, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (04) :1865-1868

[5] Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by β1-integrin signaling in rat adipocytes [J].

Guilherme, A ;

Czech, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (50) :33119-33122

[6] Localization of the insulin receptor in caveolae of adipocyte plasma membrane [J].

Gustavsson, J ;

Parpal, S ;

Karlsson, M ;

Ramsing, C ;

Thorn, H ;

Borg, M ;

Lindroth, M ;

Peterson, KH ;

Magnusson, K ;

Strålfors, P .

FASEB JOURNAL, 1999, 13 (14) :1961-1971

[7] Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate [J].

Jiang, T ;

Sweeney, G ;

Rudolf, MT ;

Klip, A ;

Traynor-Kaplan, A ;

Tsien, RY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (18) :11017-11024

[8] Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 [J].

Levkowitz, G ;

Waterman, H ;

Ettenberg, SA ;

Katz, M ;

Tsygankov, AY ;

Alroy, I ;

Lavi, S ;

Iwai, K ;

Reiss, Y ;

Ciechanover, A ;

Lipkowitz, S ;

Yarden, Y .

MOLECULAR CELL, 1999, 4 (06) :1029-1040

[9] Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action [J].

Sharma, PM ;

Egawa, K ;

Huang, Y ;

Martin, JL ;

Huvar, I ;

Boss, GR ;

Olefsky, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) :18528-18537

[10] Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes [J].

Sharma, PM ;

Egawa, K ;

Gustafson, TA ;

Martin, JL ;

Olefsky, JM .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (12) :7386-7397

← 1 →