Effects of leaf aqueous extract of Bidens pilosa (Asteraceae) on KCl- and norepinephrine-induced contractions of rat aorta

The effect of leaf aqueous extract of Bidens pilosa Linn. on KCl- and norepinephrine-induced contractions of rat aortic strips was studied. In aortic strips with endothelium intact, contractions induced using 60 mM KCl and 10(-5) M norepinephrine were dose-dependently relaxed by the extract, a more significant effect being seen with norepinephrine-induced contractions. Following mechanical damage to the aortic endothelium, inhibition of contractions was more prominent (105%) with the norepinephrine-induced contractions compared with KCl-induced contractions (15%) when the maximal dose (8 mg/mI) of the extract was used. The results suggest that the relaxation effect of the extract may be due to the blockade of the influx of extracellular Ca2+ into the cell. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.