Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

被引：35

作者：

Parlowsky, T

Welzel, J

Amagai, M

Zillikens, D

Wygold, T

机构：

[1] Med Univ Lubeck, Dept Dermatol, D-23538 Lubeck, Germany

[2] Keio Univ, Tokyo, Japan

[3] Med Univ Lubeck, Dept Pediat, D-23538 Lubeck, Germany

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2003年 / 48卷 / 04期

关键词：

D O I：

10.1067/mjd.2003.170

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates. (J Am Acad Dermatol 2003;48:623-5.).

引用

页码：623 / 625

页数：3

共 9 条

[1]

Amagai M, 1999, BRIT J DERMATOL, V140, P351

[2] Making sense of antigens and antibodies in pemphigus [J].