Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins

被引：159

作者：

Kasimsetty, Sashi G. ^{[1
]}

Bialonska, Dobroslawa ^{[1
,3
]}

Reddy, Muntha K. ^{[1
]}

Ma, Guoyi ^{[2
]}

Khan, Shabana I. ^{[1
,2
]}

Ferreira, Daneel ^{[1
,2
]}

机构：

[1] Univ Mississippi, Dept Pharmacognosy, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Natl Ctr Nat Prod Res, University, MS 38677 USA

[3] Jagiellonian Univ, Inst Environm Sci, PL-30387 Krakow, Poland

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2010年 / 58卷 / 04期

关键词：

Ellagitannins; urolithins; pomegranate juice; colon cancer; chemoprevention; ANTIOXIDANT ACTIVITY; ELLAGIC ACID; APOPTOSIS; JUICE; CELLS; DIET; RAT; TRANSCRIPTION; PUNICALAGIN; METABOLITES;

D O I：

10.1021/jf903762h

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Pomegranate juice derived ellagitannins and their intestinal bacterial metabolites, urolithins, inhibited TCDD-induced CYP1-mediated EROD activity in vitro with IC50 values ranging from 56.7 mu M for urolithin A to 74.8 mu M for urolithin C. These compounds exhibited dose- and time-dependent decreases in cell proliferation and clonogenic efficiency of HT-29 cells. Inhibition of cell proliferation was mediated through cell cycle arrest in the G(0)/G(1) and G(2)/M stages of the cell cycle followed by induction of apoptosis. These results indicate that the ellagitannins and urolithins released in the colon upon consumption of pomegranate juice in considerable amounts could potentially curtail the risk of colon cancer development, by inhibiting cell proliferation and inducing apoptosis.

引用

页码：2180 / 2187

页数：8

共 36 条

[1]

[Anonymous], 1999, Nutrition

[2] Molecular pathogenesis of colorectal cancer - Implications for molecular diagnosis [J].

Arnold, CN ;

Goel, A ;

Blum, HE ;

Boland, CR .

CANCER, 2005, 104 (10) :2035-2047

[3] ELLAGIC ACID INDUCES TRANSCRIPTION OF THE RAT GLUTATHIONE S-TRANSFERASE-YA GENE [J].

BARCH, DH ;

RUNDHAUGEN, LM ;

PILLAY, NS .

CARCINOGENESIS, 1995, 16 (03) :665-668

[4] Structure-function relationships of the dietary anticarcinogen ellagic acid [J].

Barch, DH ;

Rundhaugen, LM ;

Stoner, GD ;

Pillay, NS ;

Rosche, WA .

CARCINOGENESIS, 1996, 17 (02) :265-269

[5] Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay [J].

Bialonska, Dobroslawa ;

Kasimsetty, Sashi G. ;

Khan, Shabana I. ;

Ferreira, Daneel .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (21) :10181-10186

[6] Pomegranate juice supplementation in chronic obstructive pulmonary disease:: a 5-week randomized, double-blind, placebo-controlled trial [J].

Cerdá, B ;

Soto, C ;

Albaladejo, MD ;

Martínez, P ;

Sánchez-Gascón, F ;

Tomás-Barberán, F ;

Espín, JC .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2006, 60 (02) :245-253

[7] Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice [J].

Cerdá, B ;

Llorach, R ;

Cerón, JJ ;

Espín, JC ;

Tomás-Barberán, FA .

EUROPEAN JOURNAL OF NUTRITION, 2003, 42 (01) :18-28

[8] Inhibition of human cytochrome CYP1 enzymes by flavonoids of St. John's wort [J].

Chaudhary, A ;

Willett, KL .

TOXICOLOGY, 2006, 217 (2-3) :194-205

[9]

Chiu BCH, 2003, CANCER EPIDEM BIOMAR, V12, P201

[10] MUTATION SPECTRUM OF CIGARETTE-SMOKE CONDENSATE IN SALMONELLA - COMPARISON TO MUTATIONS IN SMOKING-ASSOCIATED TUMORS [J].

DEMARINI, DM ;

SHELTON, ML ;

LEVINE, JG .

CARCINOGENESIS, 1995, 16 (10) :2535-2542

← 1 2 3 4 →