Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

被引：910

作者：

Sistigu, Antonella ^{[1
,2
,3
,4
,33
]}

Yamazaki, Takahiro ^{[1
,2
,3
,33
]}

Vacchelli, Erika ^{[1
,3
,5
,33
]}

Chaba, Kariman ^{[5
,6
,7
]}

Enot, David P. ^{[5
,6
,7
]}

Adam, Julien ^{[1
,8
,9
]}

Vitale, Ilio ^{[10
]}

Goubar, Aicha ^{[1
,11
]}

Baracco, Elisa E. ^{[1
,3
,5
]}

Remedios, Catarina ^{[1
,2
,3
]}

Fend, Laetitia ^{[1
,2
,12
]}

Hannani, Dalil ^{[1
,2
,3
]}

Aymeric, Laetitia ^{[1
,2
,3
]}

Ma, Yuting ^{[1
,3
,5
]}

Niso-Santano, Mireia ^{[1
,3
,5
]}

Kepp, Oliver ^{[1
,3
,5
]}

Schultze, Joachim L. ^{[13
]}

Tueting, Thomas ^{[14
]}

Belardelli, Filippo ^{[4
]}

Bracci, Laura ^{[4
]}

La Sorsa, Valentina ^{[4
]}

Ziccheddu, Giovanna ^{[4
]}

Sestili, Paola ^{[4
]}

Urbani, Francesca ^{[4
]}

Delorenzi, Mauro ^{[15
,16
,17
]}

Lacroix-Triki, Magali ^{[18
]}

Quidville, Virginie ^{[1
]}

Conforti, Rosa ^{[1
,2
,19
,20
]}

Spano, Jean-Philippe ^{[20
]}

Pusztai, Lajos ^{[21
]}

Poirier-Colame, Vichnou ^{[1
,2
,19
]}

Delaloge, Suzette ^{[1
,8
]}

Penault-Llorca, Frederique ^{[22
]}

Ladoire, Sylvain ^{[23
,24
,25
]}

Arnould, Laurent ^{[23
,24
,25
]}

Cyrta, Joanna ^{[1
]}

Dessoliers, Marie-Charlotte ^{[1
,11
]}

Eggermont, Alexander ^{[3
]}

Bianchi, Marco E. ^{[26
]}

Pittet, Mikael ^{[27
,28
]}

Engblom, Camilla ^{[27
,28
]}

Pfirschke, Christina ^{[27
,28
]}

Preville, Xavier ^{[12
]}

Uze, Gilles ^{[29
]}

Schreiber, Robert D. ^{[30
]}

Chow, Melvyn T. ^{[31
]}

Smyth, Mark J. ^{[31
,32
]}

Proietti, Enrico

Andre, Fabrice ^{[1
,3
,8
,9
,11
]}

Kroemer, Guido ^{[1
,5
,6
,7
,33
,34
]}

机构：

[1] Gustave Roussy Canc Campus, Villejuif, France

[2] INSERM, U1015, Villejuif, France

[3] Univ Paris Saclay, Fac Med, Le Kremlin Bicetre, France

[4] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy

[5] INSERM, U848, Villejuif, France

[6] Ctr Rech Cordeliers, Equipe Labellisee Ligue Nationale Canc 11, Paris, France

[7] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[8] Gustave Roussy Canc Campus, Dept Biol & Pathol, Villejuif, France

[9] Gustave Roussy Canc Campus, Dept Med Oncol, Villejuif, France

[10] Regina Elena Inst Canc Res, Rome, Italy

[11] INSERM, U981, Villejuif, France

[12] Transgene SA, Illkirch Graffenstaden, France

[13] Univ Bonn, Lab Genom & Immunoregulat Life & Med Sci LIMES, Bonn, Germany

[14] Univ Hosp Bonn, Dept Dermatol, Lab Expt Dermatol, Bonn, Germany

[15] SIB, Lausanne, Switzerland

[16] Ecole Polytech Fed Lausanne, Sch Life Sci, ISREC, Natl Ctr Competence Res NCCR Mol Oncol, Lausanne, Switzerland

[17] CHU Vaudois, Dept Format & Rech, Lausanne, Switzerland

[18] Ctr Claudius Regaud, Dept Pathol, Toulouse, France

[19] Ctr Clin Invest Biotherapies Canc CICBT 507, Villejuif, France

[20] Hop La Pitie Salpetriere, Dept Med Oncol, Paris, France

[21] Yale Univ, Sch Med, New Haven, CT USA

[22] Univ Auvergne, EA ERTICa 4677, Dept Pathol, Jean Perrin Ctr, Clermont Ferrand, France

[23] Ctr Georges Francois Leclerc, Dept Med Oncol, Dijon, France

[24] INSERM, Fac Med CRI 866, Dijon, France

[25] Univ Burgundy, Dijon, France

[26] San Raffaele Univ & Sci Inst, Milan, Italy

[27] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[28] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[29] Univ Montpellier 2, CNRS, UMR5235, Montpellier, France

[30] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[31] Queensland Inst Med Res, Herston, Qld 4006, Australia

[32] Univ Queensland, Sch Med, Herston, Qld, Australia

[33] Gustave Roussy Canc Campus, Metabol Platform, Villejuif, France

[34] Hop Europeen Georges, AP HP, Paris, France

来源：

NATURE MEDICINE | 2014年 / 20卷 / 11期

基金：

英国医学研究理事会; 欧洲研究理事会;

关键词：

TOLL-LIKE RECEPTOR-3; DOUBLE-STRANDED-RNA; BREAST-CANCER; IMMUNE-RESPONSES; ANTICANCER CHEMOTHERAPY; DENDRITIC CELLS; RIG-I; INNATE; TUMORS; GENE;

D O I：

10.1038/nm.3708

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell-mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulate the rapid production of type I interferons (IFNs) by malignant cells after activation of the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3). By binding to IFN-alpha and IFN-beta receptors (IFNARs) on neoplastic cells, type I IFNs trigger autocrine and paracrine circuitries that result in the release of chemokine (C-X-C motif) ligand 10 (CXCL10). Tumors lacking TIr3 or Ifnar failed to respond to chemotherapy unless type I IFN or Cxcl10, respectively, was artificially supplied. Moreover, a type I IFN-related signature predicted clinical responses to anthracycline-based chemotherapy in several independent cohorts of patients with breast carcinoma characterized by poor prognosis. Our data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens. We surmise that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.

引用

页码：1301 / 1309

页数：9

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