Tumour necrosis factor α:: a key regulator of adipose tissue mass

被引：138

作者：

Warne, JP ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Neuroendocrinol, Div Neurosci & Psychol Med, London W12 0NN, England

来源：

JOURNAL OF ENDOCRINOLOGY | 2003年 / 177卷 / 03期

关键词：

D O I：

10.1677/joe.0.1770351

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In addition to its established role in the immune system, tumour necrosis factor alpha (TNFalpha) exerts complex regulatory actions on adipose tissue. TNalpha is produced in and secreted by the adipocyte and thus is in a position to exert a paracrine and/or autocrine role within adipose tissue. TNFalpha affects many aspects of adipocyte function, from adipocyte development to lipid metabolism. Bringing together all of these diverse actions, TNFalpha appears to play a general role in reducing adipose tissue mass. Dysregulation of TNFalpha production and/or action could be one facet in the development of cachexia and obesity, as well as associated metabolic disorders such as insulin resistance.

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收藏

页码：351 / 355

页数：5

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