Origin of a substantial fraction of human regulatory sequences from transposable elements

被引：418

作者：

Jordan, IK

Rogozin, IB

Glazko, GV

Koonin, EV

机构：

[1] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA

[2] Penn State Univ, Inst Mol Evolut Genet, Mueller Lab 328, University Pk, PA 16802 USA

[3] Penn State Univ, Dept Biol, Mueller Lab 328, University Pk, PA 16802 USA

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(02)00006-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transposable elements (TEs) are abundant in mammalian genomes and have potentially contributed to their hosts' evolution by providing novel regulatory or coding sequences. We surveyed different classes of regulatory region in the human genome to assess systematically the potential contribution of TEs to gene regulation. Almost 25% of the analyzed promoter regions contain TE-derived sequences, including many experimentally characterized cis-regulatory elements. Scaffold/matrix attachment regions (S/MARs) and locus control regions (LCRs) that are involved in the simultaneous regulation of multiple genes also contain numerous TE-derived sequences. Thus, TEs have probably contributed substantially to the evolution of both gene-specific and global patterns of human gene regulation.

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页码：68 / 72

页数：5

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